Acute phase proteins, cytokines and chemokines Adhesion molecules and ECM components Factors directly affecting metabolism α1-acid-glycoprotein α2-macroglobulin Adipocyte fatty acid binding protein (aP2) Chemerin Collagen I, III, IV, VI Adiponectin…
Fig. 9.1 Dendritic cell paradigm during steady state and activation. Cutaneous dendritic cells (DC) include Langerhans cells (LC) in the epidermis and CD11b + and CD103+ dermal dendritic cells (dDC)…
Mouse Human Unique Shared Unique Shared ILC1 NK IL-12Rβ2 CD127 (not on NK) CD90 (not on NK, ILC1) CD117 (not on NK, ILC1, NCR- ILC3) IL-12Rβ2 CD127 (not on…
TLR Ligand [102, 103] TLR1 Lipopeptide (Pam3csk4) TLR2 Peptidoglycan, Zymosan, LTA, Lipopeptide (Pam3csk4) TLR3 PolyI:C (dsRNA) TLR4 LPS, RSV protein F, Mycobacterium tuberculosis TLR6 Peptidoglycan, Zymosan TLR9 Bacterial DNA (CpG…
Organ or site Diagnostic (sufficient to establish the diagnosis of chronic GVHD) Distinctive (seen in chronic GVHD, but insufficient alone to establish a diagnosis) Other features or unclassified entities Skin…
Host variables Recipient age <1 or >10 years [10] Malignancy as indication for transplant, as well as features of more advanced disease (WBC >50 × 109/L and cytogenetic abnormalities t(4;11),…
Common manifestations Atypical manifestations aGVHD cGVHDa aGVHD cGVHD Maculopapular rash Poikiloderma Eczematous eruptions (contact dermatitis [2], eczema craquele [3]) Eczematous eruptions [4, 5] (atopic dermatitis [6], eczema craquele [7], and…
Fig. 3.1 Erythema of the face with accentuation of the ear Fig. 3.2 Erythema of the ear Fig. 3.3 Palmar erythema Fig. 3.4 Palmar erythema (Note microvesicles that herald edema.)…
Lerner grading system [11] Horn grading system [7] Grade 0 Normal skin or unrelated cutaneous disease Grade 1 Vacuolar alteration Vacuolar alteration Grade 2 Spongiosis and dyskeratosis (eosinophilic bodies)…
Fig. 10.1 Poikilodermic cGVHD on the neck and upper chest Fig. 10.2 Lichen planus–like chronic graft-versus-host disease (cGVHD). (a) Woman with lichen planus–like cGVHD on the face. (b) Man with…
