Common manifestations Atypical manifestations aGVHD cGVHDa aGVHD cGVHD Maculopapular rash Poikiloderma Eczematous eruptions (contact dermatitis [2], eczema craquele [3]) Eczematous eruptions [4, 5] (atopic dermatitis [6], eczema craquele [7], and…
Lerner grading system [11] Horn grading system [7] Grade 0 Normal skin or unrelated cutaneous disease Grade 1 Vacuolar alteration Vacuolar alteration Grade 2 Spongiosis and dyskeratosis (eosinophilic bodies)…
Fig. 10.1 Poikilodermic cGVHD on the neck and upper chest Fig. 10.2 Lichen planus–like chronic graft-versus-host disease (cGVHD). (a) Woman with lichen planus–like cGVHD on the face. (b) Man with…
Fig. 11.1 Cleansing daily with soap and warm water should be encouraged for patients with sclerotic chronic GVHD. Before (a) and after (b); 2 days of soap and water cleansing…
Category Symptoms after DLI or HSCT Acute features Chronic features Classic acute < 100 days Yes No Persistent, recurrent and late-onset > 100 days Yes No Overlap > 100 days…
Fig. 4.1 Ocular graft-versus-host disease. Ocular GVHD can affect almost every structure of the eye. Distinctive characteristics of chronic ocular GVHD include keratoconjunctivitis sicca, confluent areas of punctate keratopathy, and…
Fig. 1.1 Increasing numbers of patients are undergoing allogeneic hematopoietic stem cell transplantation (HSCT) every year (Adapted from Pasquini and Zhu [1]; with permission) Historical Perspective Pioneering experimentation by Jacobson…
Cell subset Risk of cGVHD References Effector memory CD4EM T cells (CCR7neg CD62Llow) Increase in this T-cell subset co-related with increased risk of cGVHD Yamashita et al. [7] CD8+ Central…
(1) Division of Plastic-, Hand-, and Microsurgery Department of Surgery, Ludwig Maximilians University, Munich, Germany 5.1 Introductory Text Between June 23, 1980, the first lymphatic vessel transplantation in man…
(1) Division of Plastic-, Hand-, and Microsurgery Department of Surgery, Ludwig Maximilians University, Munich, Germany 3.1 Indication and Prerequisites Circumscribed impairment of the lymphatic system is the main indication…
