Fig. 7.1 Major Th2-related cytokines. Th2 cells secrete various cytokines. IL-4 and IL-13 promote Th2 differentiation, IgE generation, and inflammation and disrupt epidermal barrier function. IL-5 is implicated in eosinophil…
Fig. 10.1 The clinical features of AD vary depending on patient age and duration of disease. In infancy and childhood, AD is characterized by eczematous changes accompanied by strong itching….
Fig. 9.1 Dysregulated cytokine network in the pathogenesis of AD. Various environmental factors act on keratinocytes (KC) inducing epithelial cell-derived cytokines—TSLP, IL-33, and IL-25. These cytokines initiate type 2 inflammation…
© Springer Nature Singapore Pte Ltd. 2018Ichiro Katayama, Hiroyuki Murota and Takahiro Satoh (eds.)Evolution of Atopic Dermatitis in the 21st Centuryhttps://doi.org/10.1007/978-981-10-5541-6_3 3. Epidemiology of Childhood AD in Asian Countries Yasuyuki Sumikawa1 (1) Department of Dermatology, School of…
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