Chromosome Locus Population Reference 11q13.5 C11ORF30/LRRC32 (GARP) European [5] 1p21.3 FLG Chinese Han [6] 5q22.1 TMEM232/SLC25A46 20q13.33 TNFRSF6B/ZGPAT 11q13.1 OVOL1 European [9] 19p13.2 ACTL9 5q31.1 KIF3A/RAD50/IL13 …
© Springer Nature Singapore Pte Ltd. 2018Ichiro Katayama, Hiroyuki Murota and Takahiro Satoh (eds.)Evolution of Atopic Dermatitis in the 21st Centuryhttps://doi.org/10.1007/978-981-10-5541-6_29 29. Clinical Questions: Lifestyle of Japan and Atopic Dermatitis Takeshi Nakahara1 (1) Division of Skin Surface…
Organ Symptoms Skin Erythema, urticaria, angioedema, pruritus, burning, sensation, eczema Mucous membrane Eye symptoms: Conjunctival hyperemia and edema, pruritus, lacrination, blepharedema Nasal symptoms: Rhinorrhea, nasal congestion, sneezing Oral symptoms: Discomfort/swelling…
© Springer Nature Singapore Pte Ltd. 2018Ichiro Katayama, Hiroyuki Murota and Takahiro Satoh (eds.)Evolution of Atopic Dermatitis in the 21st Centuryhttps://doi.org/10.1007/978-981-10-5541-6_22 22. Drug Therapy: Systemic Norito Katoh1 (1) Department of Dermatology, Graduate School of Medical Science, Kyoto…
© Springer Nature Singapore Pte Ltd. 2018Ichiro Katayama, Hiroyuki Murota and Takahiro Satoh (eds.)Evolution of Atopic Dermatitis in the 21st Centuryhttps://doi.org/10.1007/978-981-10-5541-6_21 21. Management: Drug Therapy—Ointment Takahiro Satoh1 (1) Department of Dermatology, National Defense Medical College, 3-2 Namiki,…
Fig. 6.1 Scheme of a cornified layer barrier: the lamella granules and the keratohyalin granules in the epidermis play important roles in the formation of a mature stratum corneum. The…
Fig. 7.1 Major Th2-related cytokines. Th2 cells secrete various cytokines. IL-4 and IL-13 promote Th2 differentiation, IgE generation, and inflammation and disrupt epidermal barrier function. IL-5 is implicated in eosinophil…
Fig. 10.1 The clinical features of AD vary depending on patient age and duration of disease. In infancy and childhood, AD is characterized by eczematous changes accompanied by strong itching….
Fig. 9.1 Dysregulated cytokine network in the pathogenesis of AD. Various environmental factors act on keratinocytes (KC) inducing epithelial cell-derived cytokines—TSLP, IL-33, and IL-25. These cytokines initiate type 2 inflammation…
© Springer Nature Singapore Pte Ltd. 2018Ichiro Katayama, Hiroyuki Murota and Takahiro Satoh (eds.)Evolution of Atopic Dermatitis in the 21st Centuryhttps://doi.org/10.1007/978-981-10-5541-6_3 3. Epidemiology of Childhood AD in Asian Countries Yasuyuki Sumikawa1 (1) Department of Dermatology, School of…
