Dermoscopy
Fig. 13.1 Jagged proximal edge with spikes of the onycholytic area: spiked pattern, indentations at the proximal edge of the area with onycholysis Fig. 13.2 Longitudinal striae. Longitudinal striae of…
Predisposing Factors for Onychomycosis
Fig. 2.1 Distal lateral subungual onychomycosis due to T. rubrum in two sisters Several studies have identified a possible role of HLA in the immune response of T cells to…
Onychomycosis: Role of Histopathology
Fig. 12.1 Longitudinal nail biopsy of an onychomycotic nail. The nail plate of the matrix and proximal nail bed is dystrophic showing an irregular, fragmented, and lifted surface with mounds…
Candida Onychomycosis
Fig. 8.1 Paronychia Other clinical findings comprise fungal melanonychia (Fig. 8.2), with a greenish, brownish, or even black nail discoloration [23]. Fig. 8.2 Fungal melanonychia due to Candida Diagnostic Clues…
Fungi and the Nails
Fig. 1.1 Candida onychomycosis in a patient with chronic mucocutaneous candidiasis Aside from the multiple fungal culprits, there are also multiple routes of invasion that fungi can use to infect…
Molecular Techniques (PCR)
Fig. 11.1 Map of rDNA locus from Trichophyton rubrum The region ITS1 can be amplified from a wide variety of fungus by using the primers ITS1 (5-TCCGTAGGTGAACCTTGCGG-3) and ITS2 (5-GCTGCGTTCTTCATCGATGC-3)….
Endonyx Onychomycosis
Present features Absent features Normal nail plate surface Superficial desquamation Normal nail plate thickness Hyperkeratosis Nail plate firmly attached to the nail bed Onycholysis Milky-white nail plate discoloration Subungual changes…
Myths in Treating Onychomycosis
© Springer International Publishing Switzerland 2017Antonella Tosti, Tracey C. Vlahovic and Roberto Arenas (eds.)Onychomycosis10.1007/978-3-319-44853-4_23 23. Myths in Treating Onychomycosis Tracey C. Vlahovic1 and Cara L. Dawes2 (1) Department of Podiatric Medicine, Temple University School of Podiatric Medicine, 148 N 8th…
New Topical and Systemic Antifungals
Polyenes Azoles Allylamines Β-Glucan synthase inhibitors (echinocandins) Pyrimidine analogues Mitotic inhibitors Aminoacyl-tRNA synthetase inhibitors Others Allylamines, terbinafine and naftifine, appeared in the 1990s and amorolfine years later. Echinocandins, as anidulafungin,…
New Topical Antifungals
© Springer International Publishing Switzerland 2017Antonella Tosti, Tracey C. Vlahovic and Roberto Arenas (eds.)Onychomycosis10.1007/978-3-319-44853-4_21 21. New Topical Antifungals Tracey C. Vlahovic1 (1) Department of Podiatric Medicine, Temple University School of Podiatric Medicine, 148 N 8th Street, Philadelphia, 19107,…
