As the homogentisic acid accumulates in these patients, it eventually begins depositing in skin and cartilage tissue, for which it has an affinity, becoming visibly noticeable in the fourth decade…
Treatment: Therapy is difficult. No randomized prospective studies have been performed on this rare condition, so only anecdotal therapies have been reported. Topical and oral steroids have been somewhat successful….
Treatment: Treatment is supportive. Underlying infections need to be treated adequately. The main goals are pain control and prevention of secondary infection. If the patient’s neutrophilic eccrine hidradenitis is caused…
Treatment: Treatment is typically initiated with the use of high-potency topical steroids. It may seem counterintuitive to treat an atrophic condition with topical corticosteroid creams, which can cause atrophy. In…
Antihistamines are the mainstay of therapy. The leukotriene inhibitors are also used as adjunctive therapy to the antihistamines. Cromolyn is a mast cell stabilizer that is not absorbed through the…
Measurement of the serum tryptase level is the most accurate means of screening for systemic involvement with mastocytosis. Levels in the normal range indicate cutaneous disease only; levels greater than…
Treatment: Venous insufficiency is treated with a combination of compression and leg elevation. Losing weight and increasing the activity level may also help. Arterial insufficiency is best treated surgically with…
Treatment: Isolated lesions can be treated with topical corticosteroids. Up to two thirds of skin lesions resolve spontaneously. Patients with widespread disease present a therapeutic challenge. Ultraviolet phototherapy, oral corticosteroids,…
