Syringomas



Syringomas


Christopher G. Bunick

Amanda Zubek

Macrene Alexiades



BACKGROUND

Syringomas are benign tumors of the sweat gland. Historically thought to be of eccrine origin, they may arise from either eccrine or apocrine elements. These lesions are more common in women and most commonly are found on the face in a periorbital distribution. Syringomas are often cosmetically distressing to the patient. Treatment of syringomas is based on destructive modalities and can be challenging because of frequent recurrence.


PRESENTATION

Patients present with solitary or multiple small asymptomatic or mildly itchy skin-colored bumps on the lower eyelids.




PATHOGENESIS

Syringomas are a benign sweat duct tumor and histologically appear as “tadpole” or comma-shaped eccrine duct formations. The molecular pathways involved in their formation remain to be elucidated; however, it has been postulated that the mechanism for eruptive syringoma involves infiltration of CD4+ and CD8+ T cells leading to autoimmune destruction of the acrosyringium.3 This in turn leads to proliferation of dermal eccrine ducts and fibrous stroma.

Jun 29, 2020 | Posted by in Dermatology | Comments Off on Syringomas
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