Introduction
The quality of life in developed countries has improved over the past 50 years, increasing the average lifespan by nearly 30 years. Individuals aged 65 years and over account for 13% of the US population. This “elderly” population is the fastest growing demographic and projected to double from 40.2 million in 2010 to 88.5 million by 2050. Such population aging is unprecedented. By 2050, the number of older adults in the world is expected to exceed the number of young adults for the first time in history. This trend presents a special challenge because older adults will constitute an ever-growing segment of the average surgeon’s practice and will influence clinical decisions, ethical decisions, and healthcare costs.
A multicenter study conducted in Tokyo found that 25% of burned patients were older than 65 years of age. A systematic review of more than 186,500 patients in Europe showed that 10% to 16% were in this age range. In the United States, geriatric patients constitute about 10% of the major burn population. The anticipated rise in the geriatric population makes understanding age-related physiologic and metabolic changes even more important for burn care professionals. The elderly are the age group most likely to die from severe burns. Adults older than 65 years have a mortality rate from burns that is five times the national average. , Treatment of these patients remains a greater challenge than treatment of middle-aged and younger patients because of lower physiologic reserves, higher underlying comorbidities, and limited rehabilitative capacity.
Epidemiology
Burn injuries of the elderly occur mostly due to three major mechanisms: smoking-related accidents, mishaps while cooking, and scald burns. Contact with flame is the main (54%) cause of burn injury. One-third of injuries result from cooking accidents: scalds in 22% of cases and contact with hot objects in about 6% of cases. , , The latter cause is more prevalent in older adults, reflecting increased psychological and physical disability. Smoking accidents are also reflected in the rate of fire-related deaths in individuals older than 75 years old, which is four times the national average. Smoking-related burns are exacerbated by home oxygen therapy, which is common among the elderly, combined with an estimated proportion of 20% to 40% of patients who actively continue smoking despite oxygen therapy. The male-to-female ratio decreases progressively as age increases, with women exceeding the number of men in the 75 years and older group (compared with the 5:1 male-to-female ratio for young adult burn patients). Common problems of geriatric patients that may reduce the ability to assess or control potentially dangerous behavior include diminished sensory function, cognitive defects (with or without dementia), substance abuse, and polypharmacy. , , Most burns in older adults occur at home; therefore prevention must be focused on the home environment. , Sustainable efforts to educate seniors on burn prevention, the development and availability of fire-safe cigarettes, the use of timers to turn off kitchen appliances automatically, installation of specialized smoke alarms (such as low-frequency, extra-loud alarms or bed-shaking functions), as well as home safety inspections may aid in reducing the incidence of burns in the elderly. , Prevention should also focus on the fact that 30% of geriatric patients are the victims of self-neglect (often due to failed attempts to retain independence), and at least 10% are the victims of elder abuse.
Outcome
Mortality rates have diminished among all age groups in recent decades. , , Technological progress and advances in fluid resuscitation, early burn wound excision, skin grafting, and pharmacotherapy have improved survival. The Baux score is calculated as a sum of age and percent total body surface area (TBSA) and illustrates both the influence of age on outcome and the improvements in burn care: When compared over time, the score at which the survival rate reaches 0% has steadily increased from 100 in the 1940s to 130 to 140 in the early 2000s. However, mortality and morbidity rates remain higher in geriatric burn patients. , , , , , A large registry study of Jeschke et al. reported the LD 50 (50% mortality) for 50-year-old patients at burn sizes of 50% TBSA. This LD 50 considerably drops to 30% to 40% TBSA for patients older than 65 years to only 25% for those older than 70. Pereira et al. have found in a large study of mortality trends and autopsy data that LD 50 for older adults has remained steady at 35% for decades, which is disconcerting in the light of the overall improvement of burn care. Lung injury and sepsis were the most common primary causes of death noted in burn patients, and an increase in the weights of heart, lung, spleen, and liver was noted in all age groups postmortem. Pomahac et al. reported that increased levels of creatinine at the time of admission were associated with increased mortality in older adults.
Age, TBSA burned, and inhalation injury are associated with increased mortality rates. The mortality rate is 7.4% for all patients with burn injuries aged 60 to 69 years, 12.9% for patients aged 70 to 79 years, and 21% for patients older than 80 years of age.
Geriatric patients also experience greater long-term disability after burn injury. Only about 50% of elderly patients with a major burn return home within the first year, , , and any loss of function, strength, or independence is more difficult to recover than in the younger patient population. The unique risk factors present in this population explain these statistics.
Risk factors
A number of well-recognized risk factors are present in older adults. Increased risk of infections, pulmonary diseases, and sepsis, as well as the variability of comorbidities present in these patients, increase morbidity after a burn. Some of the more prominent factors are shown in Box 30.1 .
Box 30.1
Risk Factors in Elderly Patients
-
■
Chronic illness (e.g., diabetes)
-
■
Effects of aging (e.g., presbyphagia)
-
■
Cardiovascular disease (e.g., previous infarct)
-
■
Pulmonary reserve (decreased with age)
-
■
Infections (e.g., pneumonia and urinary tract infection)
-
■
Unintentional weight loss
-
■
Decrease in lean body mass (sarcopenia)
Frailty
-
■
Impaired nutrition with presence of deficiency states in energy, protein, and macronutrients
-
■
Decreased endogenous anabolic hormones
-
■
Skin aging (thin, decreased synthesis)
Frailty
As a growing body of evidence suggests that chronologic age does not necessarily correspond well with physiologic age, new predictors are needed to stratify risk for elderly burn patients. The concept of frailty aims to provide a surrogate parameter for difficult treatment, poor outcomes, and special therapeutic considerations. Frailty is broadly defined as an increased vulnerability to external and internal stressors and thus incorporates physiologic, psychosocial, and social factors. There are currently over 70 different tools to quantify frailty, ranging from objective to subjective measurements, as well as single items such as measurement of gait speed and time to get up and go, to 90-item questionnaires. Systematic and comparative studies are needed to evaluate consensus among different assessment tools and determine the best one for elderly burn patients.
Decreased cardiopulmonary reserve
Aging reduces pulmonary reserve for both gas exchange and lung mechanics. Elderly patients are more prone to pulmonary failure, one major cause of burn-related death. The presence of atherosclerosis, coronary artery disease, and previous myocardial infarction is also common. Preexisting cardiovascular disease significantly increases mortality in burn patients.
Infections
Pneumonia and urinary tract infections are the most prevalent complications in elderly burn patients. The development of pneumonia seems to correlate with male gender, TBSA burned, and the presence of inhalation injury and contributes to higher mortality rates.
Malnutrition and decreased lean body mass
Aging leads to progressive decreases in lean body mass (sarcopenia), and some degree of protein–energy malnutrition is found in more than 50% of elderly burn patients on admission. Any preexisting loss of lean body mass will result in increased morbidity, early onset of immune deficiency, organ dysfunction, weakness, and impaired wound healing. , , Losses are caused by multiple factors, including impaired nutrition, swallowing disorders (presbyphagia), reduced mobility, and age-related decreases in endogenous anabolic hormones, human growth hormone, and testosterone. , ,
Decreased anabolic activity prolongs recovery time and greatly delays restoration of muscle. Importantly, older adults respond to exogenous anabolic stimuli such as testosterone analogs, human growth hormone, and resistance exercise similarly to the younger population. At the same time, daily protein requirements are higher in older adults than in the younger population. Therefore exercise, high-protein nutrition, and anabolic agents are essential for recovery.
Aging skin and wound healing
Aging produces significant changes in the skin. Because of these changes, burns tend to be deeper in older than in younger patients. After the age of 65 years, the turnover rate of the epidermis decreases by 50%. A flattening of the rete pegs and fewer epidermal-lined skin appendages are present. These properties significantly delay healing of partial-thickness burns. ,
Additionally, a progressive thinning of the dermis occurs, along with a decrease in both collagen content and other extracellular matrix proteins, especially glycosaminoglycan, which lower skin turgor. There are also decreases in vascularity, macrophages, and fibroblasts, resulting in deeper burns and impairment of all phases of wound healing ( Box 30.2 ). ,
Box 30.2
Aging of Skin
-
■
Decreased epidermal turnover
-
■
Decrease in skin appendages
-
■
Thinning of dermis
-
■
Decreased vascularity
-
■
Decreased collagen and matrix
-
■
Decreased fibroblasts and macrophages
Immune response
It is hypothesized that aging leads to a state of “chronic inflammation” with increased baseline levels of proinflammatory cytokines that increase the vulnerability of elderly patients to negative outcomes after insults. , A recent study evaluated the unique characteristics of the inflammatory and immune response in elderly burn patients. Stanojcic et al. were able to show an uncoordinated overactivation of proinflammatory and antiinflammatory cytokines that occurred delayed by 2 weeks postburn. This functionally impaired “cytokine storm” is followed by a phase of depletion and a dampened immune reaction in nonsurviving patients. The study concludes that because of the delay in the characteristic cytokine response, it cannot be used as a predictor for mortality in older adults as opposed to adults and children.
Treatment
The increased complications seen in elderly burn patients may to a certain degree result from more cautious and less aggressive treatments. This is due to existing beliefs that elderly burn patients cannot tolerate eschar excision as well as their younger counterparts, resulting in a greater delay in the excision of burn wounds. However, despite these risk factors, elderly patients have repeatedly been shown to tolerate multiple, early surgical procedures, and early wound closure corresponds to a better outcome in these patients. In general, elderly patients are treated identically to younger patients, and most differences in burn management between patient groups are related to comorbid conditions and adversities that may arise. One unique exception to this is that massive burns are more commonly managed expectantly in older adults, and palliative care may be indicated.
Initial resuscitation
Improved fluid resuscitation is one of the factors associated with decreased mortality. Compared with younger patients, more fluid is required to resuscitate elderly patients with the same burn size to avoid hypovolemia. This is likely attributable to decreased skin turgor, which reduces resistance to fluid accumulation or edema production. Burn depth, inhalation injury, and delayed resuscitation can influence fluid requirements. In addition to the Parkland and modified Brooke formulas, Benicke et al. developed a multifactorial resuscitation formula with a compensating factor for advanced age ( Box 30.3 ). Early ventilatory support is more commonly required because of decreased lung reserve.
Box 30.3
TBSA, Total body surface area.
Parkland Formula:
Modified brooke formula:
Benicke’s formula:
Wound management
Early removal of the burn wound and rapid closure with skin grafts are essential for survival. , , Because of thinner skin, thermal injuries often create full-thickness wounds, and skin graft procurement may create significant donor site complications. Thinner skin grafts are necessary, and healing time is prolonged.
Metabolic and nutritional support
Although elderly patients do not generate the degree of hypermetabolism seen in younger patients, the catabolic response is comparable, necessitating a 1.5- to 2-g/kg/day protein intake. , In already malnourished patients, the goal of nutritional support must be not only maintenance but also replacement therapy, especially for protein and micronutrients. , Nutrient supplements are invariably required. Most supplements are protein hydrolysates because the gut is more capable of absorbing peptides and amino acids than whole proteins broken down from food. , Early enteral feeding (defined as <24 hours from admission) is associated with lower morbidity and mortality, as well as shorter intensive care unit and overall hospital stays.
Anabolic agents are valuable adjuncts to optimal nutrition. , , , The effects of insulin and oxandrolone on postburn hypercatabolism have been studied in the pediatric population, and these anabolic agents may be used in older adults, given that endogenous anabolic hormones are decreased in this group after injury.
Fram et al. demonstrated continuous insulin infusions, with tight euglycemic control, to restore insulin sensitivity, improve mitochondrial oxidative capacity, and reduce resting energy expenditure. Lower-dose infusions of 9 to 10 U/h of insulin promote substantial muscle anabolism without the need for additional large doses of carbohydrates. Intensive insulin therapy during acute care reduces morbidity, mortality, and complications caused by infection. , Testosterone restoration is effective in both male and female burn patients. However, the synthetic analog oxandrolone is preferable because it possesses only 5% of the virilizing androgenic effects of testosterone and is available in a peroral formulation. Oxandrolone restores lean body mass and improves wound healing in burned adults, especially in emaciated patients whose treatment has been delayed. , The effects of oxandrolone are independent of age but have yet to be confirmed specifically in an elderly burn patient population.
Treatment of acute pediatric burn patients with oral oxandrolone (0.1 mg/kg twice daily) enhances the efficiency of protein synthesis and increases anabolic gene expression in muscle. It also significantly increases lean body mass at 6, 9, and 12 months after burn and bone mineral content at 12 months after injury. Recombinant human growth hormone has been successfully used in pediatric patients; , however, it has several adverse effects, such as hyperglycemia. Its potential positive effects on the adult and elderly burn patient population require investigation in prospective trials.
β-Adrenergic blockade with propranolol during the acute phase and long term attenuates the effects of the burn-induced hypermetabolic response. In severely burned patients, titration of propranolol to reduce baseline heart rate by 15% to 20% improves muscle–protein balance and diminishes obligatory thermogenesis, tachycardia, cardiac work, resting energy expenditure, and fatty infiltration of the liver. , , However, no study has directly focused on geriatric patients.
Pain, sedation, and comfort care
Geriatric burn patients are often undertreated for pain because of the misconception that less pain occurs with age and fear of deleterious side effects of aggressive pain management such as diversion, dependence, or overdose. , This can be detrimental because both pain and anxiety further increase the levels of endogenous catecholamines, which increase the hypermetabolic response to severe burns. Reduced clearance of many therapeutic agents occurs with aging, necessitating lower dosages ( Table 30.1 ). For this reason, pain assessment using reliable tools is essential to create an individualized treatment plan, which should also account for any comorbid conditions that may be present on admission. Untreated pain and incorrect sedation may result in posttraumatic stress disorder, major depression, and delirium. In addition, although the burn injury primarily determines the extent of the metabolic response, metabolic rates are also increased by physical activity, background pain, procedure-related pain, and anxiety. Judicious narcotic support, appropriate sedation, and supportive psychotherapy are mandatory to minimize these effects. Combination drug therapy is often required to achieve adequate analgesia. Different approaches ranging from patient-controlled analgesia to virtual reality have been found to ameliorate pain in burned patients. Intravenous drug administration is preferable during the acute phase. A proactive geriatrics consultation team may also be beneficial in managing pain. Use of only comfort care measures needs to be considered for elderly patients with burns likely to be fatal.
Table 30.1
Commonly Used Drugs Requiring Decreased Doses in Elderly Patients
| Drug | Comments |
|---|---|
| Barbiturates | Should be avoided; paradoxical pharmacologic response, often leading to restlessness, agitation, or psychosis caused by a decreased rate of elimination |
| Benzodiazepines | Increased sensitivity to pharmacologic effect; some benzodiazepines may be metabolized more slowly |
| Narcotic analgesics | Increased sensitivity to analgesic effects: possibly impaired clearance |
| Tricyclic antidepressants | Increased incidence of cardiac and hemodynamic adverse effects; urinary retention and other anticholinergic effects; decreased drug clearance |
Perioperative optimization
Aging produces many changes in the cardiovascular system that make hemodynamic stability more difficult to achieve and increase adverse outcomes. Coronary artery disease is prevalent, being estimated to exceed 80% in patients older than 80 years of age. Elderly patients are at higher risk for congestive heart failure, and special considerations should be taken during acute and long-term treatments. The revised cardiac risk index stratifies patients into risk groups and helps identify those likely to need additional cardiac evaluation. Patients with minor perfusion abnormalities undergoing low-risk surgery may not require catheterization but should be considered for prophylactic β-blockers and aspirin before operation. High-risk subgroups of patients identified based on clinical risk factors and positive noninvasive tests should undergo cardiac catheterization. Patients with significant cardiac lesions should have definitive coronary revascularization via angioplasty before large TBSA burns are excised. The potential benefits of using β-adrenergic blocking agents during the perioperative period have been studied , because perioperative ischemic events are related to an exaggerated postoperative sympathetic response that leads to an increased heart rate. , β-Blockade has an added advantage in burn patients : severe thermal injury induces hypermetabolism that persists for up to 9 to 12 months, and the resting metabolic rate in burn patients doubles for those injuries covering greater than 40% TBSA. Catecholamines are key in the initiation of various cascades that stimulate postburn hypermetabolism. Preventing initiation of these cascades by blocking the action of catecholamines at the receptor level using β-blockers such as propranolol attenuates this response and reduces supraphysiologic thermogenesis, tachycardia, cardiac work, and resting energy expenditure.
The drawback of β-blockade in older adults is that the aging cardiovascular system is less responsive to β-receptor stimulation. This decrease, together with anesthetic agents, may lead to deleterious intraoperative hypotension in the presence of prophylactic β-blockade. Further investigations are necessary to determine the most appropriate therapeutic regimen for reducing perioperative ischemia, cardiac morbidity, and postburn hypermetabolic responses in older adults.
Pulmonary complications are more strongly linked to coexisting comorbidities than to chronologic age. Because of the prevalence of chronic obstructive pulmonary disease and asthma in older adults, physicians should be alert for these conditions during perioperative evaluation. With the appropriate diagnosis, aggressive pulmonary rehabilitation including exercise training, patient education, smoking cessation, and medication optimization is effective in elderly patients. All of these aspects must be integrated into long-term patient management. Aggressive use of antibiotics, judicious use of bronchodilators, adequate hydration, postural drainage, and chest physiotherapy reduce the incidence of pneumonia, atelectasis, and other pulmonary complications.
Rehabilitation
Burn rehabilitation is a long multidisciplinary process that aims to preserve patients’ functional ability and restore independence. Physical and occupational therapy should begin immediately after injury. Important components of rehabilitation include wound healing, scar prevention and correction, splinting, casting, traction, pressure therapy, pharmacologic therapy, exercise, and psychological support. Older adults should be aggressively managed during rehabilitation to avoid any further loss of function or strength, which are difficult to recover. Older patients are capable of recovering muscle strength with resistance exercise and should not be managed conservatively. As with children, providing support and guidance for caretakers is essential because these individuals will be responsible for the patient’s well-being upon discharge. ,
Intentional burns in older adults
Identifying physical abuse by burning in older adults is difficult because no pathognomonic signs exist. Although such abuse is relatively rare, professionals consistently underestimate the prevalence of elder abuse. The growth in the elderly population makes it necessary to raise awareness among health professionals and reevaluate the clinical approach and assessment for burn injuries inflicted intentionally or negligently. Older adults often live alone, interacting predominantly with the caregivers who enact their abuse. These patients may keep their abuse a secret because of shame, guilt, or fear of reprisals. , Most forms of intentionally inflicted burns have a higher associated morbidity and mortality than equivalent accidental burns, in part because of comorbidity from other physical abuse, substance abuse, or psychological problems that contributed to or resulted from the inflicted burn. Elder mistreatment can be associated with confidentiality difficulties because they may not want abuse reported. The priority of the examining physician is to treat life-threatening conditions. They should then promptly record symptoms and signs of abuse or neglect (including photographs). Deliberately inflicted burn injuries are best managed by a multidisciplinary team of healthcare, social service, and legal professionals.
Conclusion
Despite the remarkable reduction in mortality in burned children over recent decades, we have not yet achieved the same results in elderly patients. This age group still constitutes a major challenge. Surgical decision-making in these patients must take into account physiologic age, preburn functional status, degree of impairment from comorbid conditions, and clear treatment goals. No patient should be denied an operation based on age alone because age-related declines in organ function are predictable for the population but not necessarily for the individual. More so, the burn surgeon’s general mindset should be to treat geriatric patients as aggressively as younger patients. Currently, no “score” can improve decisions based on a thorough evaluation and discussion with the patient and family. Favorable outcomes in elderly burn patients should pertain more to relieving suffering and maintaining independence and quality of life rather than expanding lifespan. Clear, repeated communication between the burn team and patients or their surrogates is critical for guiding therapy and achieving acceptable outcomes.
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree





