Histopathologic Events of Cryolesion: An Atlas

Fig. 25.1

During the first minutes of performing cryosurgery, there is an immediate reaction that is clinically manifest as burning pain of short duration, formation of a white block of ice, and edema. Histologically, this corresponds with vasodilation or dilated blood vessels, congestion (many erythrocytes inside the vessel lumen). Some epithelial cells begin to show changes

Fig. 25.2

In the first 24 h, a blister formation was clinically observed. Most cases presented serum or blood serum content. Microscopically, epithelial necrosis was seen as well as subepidermal blister formation

Fig. 25.3

Upon a closer look, necrotic keratinocytes could be seen. An eosinophilic material was present inside the blister as well as inflammatory cells and erythrocytes

Fig. 25.4

Clinically, some blisters can be hemorrhagic. Histopathologically, one can observe the same subepidermal blister with countless erythrocytes in its cavity and dense lymphocytic inflammatory infiltrate

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