Correct diagnosis is the sine qua non for the care of any patient with any disorder. If you don’t know the diagnosis, you can’t establish the cause, provide the prognosis, or institute appropriate therapy. For patients with dermatologic disorders, a working diagnosis is almost always first established on the basis of clinical symptoms and signs. If necessary, this clinical diagnosis can subsequently be confirmed through procedures such as biopsy, cytology, and microbial culture (see Chapter 4).
There are two major approaches to using clinical symptoms and signs to establish a working diagnosis: the use of visual memory and the use of a morphologically determined approach. Dermatologists, by virtue of repeated exposure to patients with both common and uncommon diseases, almost always depend on visual memory. And, because it works for them, they use that same approach when teaching medical students and other clinicians. Thus, in the classroom or at continuing medical education courses, they bombard their audience with clinical photo after clinical photo, leaving the participants with a jumbled mass of impossible-to-remember images of skin disease.
The use of visual memory works for the dermatologist because of sufficient, repetitive exposure to these diseases. But other clinicians, encountering fewer patients with mucocutaneous disorders, lack the opportunity for sufficient visual reinforcement to dependably recognize uncommon and rare diseases. By analogy, they are put in the position of someone attending a large gathering where they know only a few of the guests. In spite of many introductions, the names of those they have newly met quickly disappear from memory. At best, on a subsequent encounter, one might remember a face as vaguely familiar but find it impossible to identify the person by name. The same problem occurs for the nondermatologist in a clinical setting. In this situation, when faced with an unrecognized mucocutaneous disorder, one might futilely turn to a standard dermatology textbook but find that the diseases in it are organized on the basis of etiology or pathophysiology. This is, of course, of no help, as one must know the diagnosis first before it is possible to make use of the material contained in such a book. As a last resort, one might then end up paging through an atlas hoping to stumble on a disease that matches what was just found on examination of the patient. At best this offers a hit-or-miss approach, and even when it is helpful, it is an inefficient and mostly inaccurate approach to diagnosis.
A better diagnostic approach for the nondermatologist is the use of a diagnostic approach in which the disorders are organized on the basis of clinical morphology. This approach directs the clinician to a cluster of diseases that share similarities in appearance. Once having arrived at the correct group of diseases, one can scan the classification table (see Table 3.1) to identify the most appropriate chapter in this book. Then, with a quick reading about the characteristic diagnostic features for the diseases contained in that chapter, together with perusal of the associated clinical photos, one can arrive at the most likely diagnosis. This diagnosis, if necessary, can be confirmed by way of a biopsy or other diagnostic test (see Chapter 4). Note that this approach even allows a clinician to make a correct diagnosis of a disorder that he or she has never previously encountered.
Of course, to use a morphologic approach such as this, one must be able to describe in dermatologic terms the features that one has seen on clinical examination. This is not very difficult because, as is true for most “foreign” languages, a relatively small number of words can serve one’s basic needs. The dermatologic words that are required for this approach are listed and defined under “Terminology” in the previous chapter (see Chapter 2).
Initial Approach to the Patient History and Physical Examination
As is true in all fields of medicine, history and physical examination represent the first two steps in diagnosis. A third step, that of utilizing diagnostic procedures to confirm a clinical diagnosis, is covered in the next chapter. There are at least two good approaches that can be used in obtaining the initial history. Some clinicians prefer using a questionnaire that can be completed by the patient either at home or in the office prior to first contact with the clinician. One of us (LE) utilizes this approach, and she has made her questionnaire available at no cost on her online site, www.libbyedwardsmd.com. This may be downloaded, modified, and subsequently used by any clinician. This approach allows the patient to express what he or she feels is important and minimizes any discomfort a patient may have about beginning a discussion about genital and/or sexual problems. Alternatively, one of us (PJL) takes the initial history after the patient is placed in the examination room but, importantly, before the patient is asked to disrobe. With either alternative, a more directed history is then taken during or after the examination.
TABLE 3.1 Clinical classification of genital dermatologic disorders
Modified from Lynch PJ, Moyal-Barracco M, Scurry J, et al. 2011 ISSVD terminology and classification of vulvar dermatological disorders: an approach to clinical diagnosis. J Low Genit Track Dis. 2012;16:139-144.
The two key points in physical examination of patients with genital problems are exposure and illumination. First, in a misguided attempt to protect patient modesty, some clinicians erroneously allow the patient to determine the extent of clothing to be removed. This leads patients to believe that they can simply pull underwear partially down or to one side whereas, in fact, all clothing covering the anogenital area should be completely removed. Second, nearly all examinations should take place with the patient lying supine on the examination table. Women can then be examined either in a “frog leg” position or with their feet in stirrups. The latter is preferred as it allows for good visualization of the anal area. Men are usually examined using the “frog leg” position as they generally strenuously resist being placed in stirrups. For men, the anal area can be examined either with the patient rolled to his side or with him standing but bending forward over the examination table. It cannot be emphasized strongly enough: the genital area in men cannot be adequately examined with the patient seated or standing straight up.
Good lighting is required for all examinations. This requires use of a light separate from a fixed ceiling light: one that is adequately bright and that is flexible enough so that it can be moved to illuminate every aspect of the anogenital region. Needless to say, except in extraordinary circumstances, examination of a patient of the sex opposite to that of the clinician should be carried out in the presence of a chaperone.
Once the examination is complete, the clinician should write, or enter, exactly what has been seen using the dermatologic terminology described in Chapter 2. In doing so, it is helpful to first determine the noun (macule, patch, papule, plaque, etc.) Once the noun (primary lesion) is determined, one can then insert the necessary adjectives (describing the surface characteristics, margination, configuration, and color) in front of the noun. If more than one lesion was present, the description, if the lesions are somewhat similar, should be of the most prototypical lesion.
When the description is complete, it is easy for the clinician to place an unidentified disease into one of the nine categories (groups) listed in Table 3.1 (see also the explanatory material in reference 1). Once that is done, the clinician simply turns to the chapter in this textbook related to that category. A quick perusal of the diagnostic material regarding the diseases discussed in that chapter allows one to put together a short list of differential diagnoses. Additional reading about each of the disorders on this short list almost always allows for identification of the single most likely diagnosis.
Therapy
This section discusses only general therapeutics; the specifics of individual therapeutic agents. Their use for a particular disorder are contained with the discussion of the diseases as they occur throughout this book.
One of the guiding principles of medical therapy is the recognition that a disease is occurring in an individual rather than existing as a separate, localized problem. This is particularly true for patients with genital disease where there are immense psychological, social, and sexual repercussions associated with every problem occurring in this region of the body. For instance, patients are highly likely to have a perception that negligence on their part regarding something they were responsible for, such as sexual activity or hygiene, led to the development of their problem. This, of course, may or may not be actually true. Therefore, look for the presence of anxiety, depression, guilt, or other aspects of psychological dysfunction in all patients with anogenital disorders. Offer support and counseling to include assistance in obtaining help by other professionals where the magnitude of the problem warrants it. Failure to recognize the patient as a person is very likely to compromise the therapeutic outcome even when the disease itself is identified and treated correctly.
Environmental Factors
The anogenital area represents a very hostile environment for normal function of the mucocutaneous epithelial cells that make up the barrier between us and the outside world. Some of the detrimental factors that are involved include heat, sweat, vaginal secretion, urine, feces, clothing, friction, and excessive hygiene. These factors can cause disease, worsen minor problems, and retard normal healing.
Epithelial cells can generally withstand rather high temperatures but, unfortunately, with heat comes sweating. And sweat can be remarkably irritating as exemplified by the discomfort experienced when sweat gets in our eyes during exercise. The retention of sweat leads to maceration, and this in turn leads to damage and possibly death of epithelial cells. This damage to the epithelial barrier allows the exposure of cutaneous nerve endings and results in symptoms of pruritus and/or pain. The presence of this warmth and moisture also fosters colonization of, and sometimes infections due to, bacteria and Candida sp. Obesity, tight clothing, and prolonged sitting (especially on vinyl or plastic seats) are often responsible for such maceration. It is difficult, but worth trying, to ameliorate these conditions.
In women, vaginal discharge (whether physiologic or pathologic) and/or urinary incontinence can cause irritation with subsequent inflammation and damage to epithelial cells. The end result is similar to that described for sweat retention. To make matters worse, women with urinary incontinence or vaginal discharge often turn to the use of panty liners on a continual basis. The result is even worse maceration. The cause of vaginal secretions (see Chapter 15) should be determined and treated appropriately. Incontinence may require urologic consultation. In both sexes, fecal soiling can lead to irritation. More careful cleaning after defecation is desirable so that sweat does not liquefy and spread irritating fecal material. Usually, careful use of ordinary toilet paper is sufficient but if that causes too much irritation, Cetaphil cleanser, mineral oil, or vegetable oil can be used for anal cleansing.
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