Martin I. Boyer
Definition: The infiltration into the subcutaneous and/or deep tissues by fluids administered usually through an intravenous cannula. It is most frequently associated with chemotherapeutic agents, phenytoin, or intravenous contrast dye.
Vasopression, or cationic cellular toxicity
Secondary bacterial infection
Expectant (ice and elevation)
Local injection of hyaluronidase 1,500 IU followed by flush with NS through multiple small incisions over the affected area
Topical free radical scavengers (dimethylsulfoxide plus topoisomerase-2 inhibitor desrazoxane IV)
Goal of treatment is to mitigate against skin loss directly over gliding tissue by local elimination (as much as possible) of the cytotoxic agent