An Overview of Therapy for Leg Veins




Introduction


Depending on the size and location of the leg veins to be treated, any of a multitude of therapeutic options may be appropriate. While selecting the correct treatment techniques is important, management of patient expectations prior to the treatment can be equally vital. A complete list of topics should be discussed with every prospective patient ( Box 5.1 ). The patient must understand that although improvement is expected, there is no guarantee regarding the degree of improvement. Risks accompany any medical procedure, and these must be discussed thoroughly. Once the physician has conveyed the necessary information, the patient should be encouraged to ask questions and should be provided with a detailed explanation of any concerns, as appropriate. If the patient appears overly anxious, overly demanding, or simply unable to understand the procedure, the patient may not be an ideal candidate for intervention.



Box 5.1

Topics of pre-treatment discussion with patient





  • Patient expectations



  • Expected discomfort during treatment



  • Number of treatments required



  • Benefits of treatment



  • Possible risks and complications of treatment



  • Treatment alternatives



  • Post-treatment care



  • Duration and nature of recovery phase






Compression


Use of external compression therapy (CT) is a fundamental strategy in the treatment of lower extremity venous disease. Despite recent therapeutic advancements in leg vein treatment, compression remains a simple, effective, and inexpensive modality. It should be considered as the primary treatment in many conditions, and as an adjunct when other treatments are employed ( Box 5.2 ).



Box 5.2

Indications for leg vein compression





  • DVT prophylaxis



  • Active DVT treatment



  • Symptomatic varicose veins



  • Chronic venous insufficiency



  • Venous ulcers



  • Post sclerotherapy



  • Post phlebectomy



  • Post endovascular ablation



  • Pregnancy



  • Thrombophlebitis






Active and Passive Compression


Compression can be either passive or active. Passive compression is applied using inelastic bandages. As muscles contract, the bandages resist the volume increase and thereby deliver increased pressure is delivered. As the muscles relax, the volume decreases so that minimal pressure is applied by the bandages. On the other hand, active compression using elastic bandages permits application of pressure both during muscular exercise and at relaxation. This constant pressure may not be tolerated by bedridden or inactive patients, and may be contraindicated in arterial insufficiency ( Fig. 5.1 ).




Figure 5.1


( A ) Before compression. ( B ) Compression shifts the venous flow from superficial to deep system


Whether passive or active, compression improves venous disease through several mechanisms. Compression narrows the lumens of the veins in the superficial system, which accelerates venous flow, decreases venous pooling, and helps to shift venous flow from the superficial into the deep venous system. Compression also may partially restore valvular function, and gradually reverse degenerative changes in the veins, thus also reducing venous reflux.




Compression Bandages ( Tables 5.1 and 5.2 ; Fig. 5.2 )



Short-stretch bandages


Various modalities are available for compression. Completely rigid inelastic bandages, like the zinc gel Unna boot (Unna-Flex, Convatec, Princeton, NJ), and the Gelocast (Beiersdorf Inc., Norwalk, CT), both dry to form a cast around the leg. Short-stretch bandages such as Comprilan (Beiersdorf, Norwalk, CT) are made of fabric that stretches 30–50%. Inelastic bandages and short-stretch bandages exert passive compression to treat edema, deep vein thrombosis (DVT), or ulcerations due to chronic venous insufficiency (CVI). They must be applied by trained staff to ensure a proper fit and remain in place for several days continuously. However, as edema remits and leg circumference decreases, the inelastic nature of the bandages fails to accommodate for this change and corresponding pressure loss can occur as early as within the first few hours of application.



Table 5.1

Manufacturers of compression stockings




























Brand Location and telephone number Website
Jobst Charlotte, NC 1-800-537-1063 www.jobst-usa.com
Sigvaris Peachtree City, GA 1-800-481-5488 www.sigvaris.com
JuZo Cuyahoga Falls, OH 1-800-222-4999 www.juzousa.com
Medi Whitsett, NC 1-888-633-6334 www.mediusa.com
Venosan Asheboro, NC 1-800-322-7744 www.venosanusa.com


Table 5.2

Manufacturers of compression bandages




































Manufacturer Type Adherence/Name
Convatec Princeton, NJ High Stretch Nonhesive/Tubigrip
Beiersdorf Norwalk, CT Low Stretch


  • Nonhesive/Comprilan



  • Cohesive/Comprihaft



  • Adhesive/Elastoplast

Beiersdorf High Stretch


  • Nonhesive/Eloflex



  • Cohesive/Elohaft

Beiersdorf Non-Stretch Cohesive/Gelocast
3M Health Care St. Paul, MN High Stretch Adhesive/Microfoam
Convatec Princeton, NJ Non-Stretch Cohesive/Unna-Flex
Conco Medical Bridgeport, CT Low Stretch Cohesive/Medi-Rip







Figure 5.2


( A–C ) Proper application of stretch bandage post sclerotherapy



Long-stretch bandages


Long-stretch bandages, made of fabric that can stretch 100–200%, provide active compression, indicated after surgery, sclerotherapy, or thrombophlebitis. Their main disadvantage is the potential hazard to patients with arterial occlusive disease. The application of bandages is dependent on the skill of the practitioner, with experienced clinicians able to consistently apply bandages with pressure ranging from 25–50 mmHg. The less experienced typically achieve pressures in a broader range, from 15–70 mmHg, and deviation on the high end can lead to arterial occlusion in those with pre-existing arterial disease. Therefore, before application, arterial flow should be evaluated by checking the ankle/brachial index, and patients should be instructed on how to properly superimpose each successive layer. After being washed, the bandages tend to lose some of their compressive capability.



Multilayer bandages


Multilayer bandages are a compromise between inelastic bandages and long-stretch elastic bandages. They are often comprised of four superimposing layers: (1) wool padding for comfort and to absorb exudates; (2) cotton bandage to hold the wool in place; (3) long-stretch elastic bandage for active compression; and finally, (4) cohesive medium-stretch bandages. The different indications for the various bandage options are not absolute as the ultimate physiologic effect can be modified by the clinician applying the bandage. Comparative studies assessing the utility of particular bandages for select indications are still inconclusive.




Compression Stockings


Stockings provide an alternative to bandages. Varying in length and by degree of compression, stockings can be used for prophylaxis against DVT or development of varicose veins. Stockings are also indicated after surgery, phlebectomy, or sclerotherapy. Compression following sclerotherapy of varicose veins and larger reticular veins is a universally accepted intervention that encourages the direct apposition of the vein walls so as to decrease the likelihood of thrombus formation and subsequent recanalization of the treated vessel. The avoidance of thrombus formation also appears to limit hyperpigmentation and thrombophlebitis and subsequent telangiectatic matting. However, the utility of stockings following treatment of small telangiectasias continues to be debated. After leg surgery or phlebectomy, stockings help prevent hematomas. During pregnancy, stockings forestall the development of varicose veins that would otherwise proliferate further due to increased venous pressure and hormonal influences. Pressure stockings are also a key element in the treatment of superficial thrombophlebitis.


There are five stocking compression classes, designated 0 to IV ( Table 5.3 ). In each class, there are available various lengths, ranging from socks, to thigh-high, to full-length pantyhose. Proper selection is contingent on the indication and the patient’s ability to tolerate compression. Elderly patients may have difficulty putting on the stockings, especially the high-compression stockings, and devices have been developed to assist these individuals. An alternative strategy is to superimpose two pairs of compression stockings, with, for example, two pairs of Class 0 stockings offering the same pressure as one pair of Class I stockings. The two separate stockings are easier to pull on. Stockings tend to lose pressure with routine use and washing, and may need to be replaced every 6 months.



Table 5.3

Classes of compression stockings




























Compression class Pressure (mmHg) Common indications
0 10–20 Mild functional venous insufficiency
I 20–30 Chronic venous insufficiency, symptomatic varicose veins, DVT
II 30–40 Symptomatic varicose veins, DVT, venous ulcers
III 40–50 Venous ulcers
IV >60 Sever symptoms, difficult to control edema, significant skin fibrosis

The above classification of compression classes may vary among different countries and different brands.


Class 0 stockings are indicated in mild functional venous insufficiency that results in minimal varicose veins with associated mild edema or leg fatigue. Chronic venous insufficiency and more severely symptomatic varicose veins should be treated with either Class I or II stockings. Class I or II stockings are also indicated in the outpatient management of DVT as they relieve pain and edema, and enhance thrombus adhesion. Leg ulcer treatment requires Class II or III stockings in addition to local skin treatment. Alternatively, ulcerations may be amenable to other types of compression treatment such as multilayer bandages or inelastic bandages. Class IV is reserved for those with severe symptoms, difficult to control edema and significant skin fibrosis.


There is no consensus on the duration or degree of compression needed after surgery. Although one study has shown equal efficacy between high and low pressure compression stockings in minimizing incidence of bruising and thrombophlebitis after varicose vein surgery, high compression stockings are clearly necessary after sclerotherapy. However, there appears to be no difference between Class I and Class II compression stockings in controlling the objective and subjective parameters of venous insufficiency. Weiss et al studied the duration of compression after sclerotherapy and found that subjects with the most improvement used 3 weeks of compression, followed by the group with 1 week of compression, followed by the group who only used compression for 3 days. All treatment groups had significant improvement compared to the control group that did not receive compression. The 1-week and 3-week groups also experienced less sclerotherapy-associated hyperpigmentation than the 3-day group and the control group.




Treatment of Small Vessel Disease


When larger truncal varicose veins are present, the associated telangiectasias cannot be successfully treated without addressing the underlying hydrostatic pressure elevation. In cases of great saphenous vein (GSV) incompetence, surgical techniques or endovenous ablative techniques may be required. Ambulatory phlebectomy allows treatment of virtually all large varicose veins while sclerotherapy can be used to treat large varicose veins and reticular varicose veins. Only after the reticular, varicose, and deep incompetent veins have been treated should attention turn to treating the superficial telangiectasias with sclerotherapy or with laser- or light-based devices. In patients with only isolated telangiectasias without pressure problems in larger vessels, sclerotherapy or laser/light therapy may be used primarily ( Fig. 5.3 ).












Figure 5.3


( A ) Visualization of the leg vein. ( B ) Two-point counterpressure applied to the injection site. ( C ) Placement of the needle into the vein at 30 degrees. ( D ) Steady injection producing immediate blanching of vessel. ( E ) Immediate application of cotton ball and tape



Sclerotherapy


The goal of sclerotherapy is to intravascularly infuse a chemical irritant to cause irreversible endothelial cellular destruction, which leads to vascular fibrosis and obliteration. Virtually any foreign substance can be utilized to induce venous endothelial damage, and several sclerosing solutions are commercially available for this purpose ( Table 5.4 ). The selection of solution type, concentration, and quantity is dictated by the type and site of the varicosity ( Fig. 5.4 ).



Table 5.4

Common sclerosing agents


































Solution Category Advantages Disadvantages Brands
Sodium tetradecyl sulfate Detergent Painful only with extravasation; capable of sclerosing larger veins; FDA approved Necrosis if extravasation with >0.25% solution; pigmentation, matting Sotradecol (Angiodynamics, Quensbury, NY) Fibrovein (STD Pharmaceuticals Inc, Hereford, UK)
Polidocanol Detergent Painless; rare necrosis; FDA approved Urticaria at injection site; no pain to warn of arteriolar injection Asclera (Merz, San Mateo, CA)
Aethoxysklerol (Kreussler, Germany)
Hypertonic saline Hyperosmolar solution Nonallergenic FDA: off-label; painful injections, necrosis, pigmentation, matting None
Glycerin Toxin Rare matting, pigmentation, necrosis Too weak for large veins; more viscous; possible allergy; FDA off-label Scleremo (Lab Therica, France)



Figure 5.4


Sclerotherapy tray consisting of: rubbing alcohol, needles and syringes, various sclerosants (shown here: 72% glycerin, 0.5% sodium tetradecyl sulfate, 0.2% sodium tetradecyl sulfate, and 0.1% sodium tetradecyl sulfate), compression bandage, three-way stopcock, gauze, tape. Not shown are cotton balls


Post-Sclerotherapy Compression


To decrease the incidence of thrombus formation, which may lead to subsequent recanalization and post-sclerosis pigmentation, compression is also an essential adjunct to sclerotherapy of large varicose veins. Moreover, direct apposition of vein walls due to external compression increases the duration of sclerosant contact with the endothelium, thus making the procedure more effective. Lastly, the reduced thrombotic and subsequent inflammatory phlebitic events may also minimize telangiectatic matting. Some authors argue that telangiectasias <1 mm require no compression after injection, but there is general agreement that sclerotherapy of larger telangiectasias, venulectasia, reticular veins, and varicose veins must be followed by several days of compression therapy. During sclerotherapy, elastic bandages are commonly applied immediately after the last sclerosant injections. Cotton balls or rubber cushions may be placed under these bandages to provide additional pressure at points of reflux or over larger veins to prevent thrombosis. Since the bandages gradually lose the compressive force as they are loosened with patient movement, many clinicians prefer compression stockings for bandages after sclerotherapy, or they will advise patients to replace the bandages with stockings a few hours after the procedure.


Patient Selection


Before embarking on sclerotherapy, a pertinent medical history should be obtained. Specifically, history of lower extremity infections, diabetes, anaphylaxis, and severe asthma should be elicited. Coagulopathies, pregnancy, history of recurrent DVT, and inability to ambulate are contraindications for sclerotherapy. Laboratory tests are usually not necessary except when hypercoagulable states are suspected. Diagnostic studies such as duplex scanning should be reserved for patients with symptomatic varicosities, varicose veins larger than 4 mm in diameter, or large numbers of spider telangiectasias that are collectively indicative of venous hypertension.


Prior to treatment, patients must understand the procedure and its limitations ( Boxes 5.3 and 5.4 ). The patient must be told that ‘perfect legs’ are not possible, although significant cosmetic improvement is likely. The physician must never promise complete clearance of all the telangiectasias, and clarify that in the best case, 3–6 treatments may provide about 80% improvement. Treated veins may recur, and new telangiectasias may appear in the future as well. Photographs are useful for both the physician and the patient to document the progress of the treatment. Photographs not only define the pre-treatment extent and the locations of varicose, reticular and telangiectatic veins, but they also document pre-existing scarring or pigmentation.


Apr 10, 2019 | Posted by in Dermatology | Comments Off on An Overview of Therapy for Leg Veins
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