8. Multimodal Analgesia for the Aesthetic Surgery Patient
Understanding Multimodal Pain Management
“Prescription drug overdose is an epidemic in the United States. All too often, in far too many communities, the treatment is becoming the problem.” 1
80% of patients experience acute pain after surgery.
75% of U.S. patients report surgical pain rated 7 or higher (scale of 1–10).
59% of patients are concerned about postoperative pain. 2
Opioid Epidemic
November 2016: U.S. Surgeon General declares epidemic of addiction—public health crisis 3
United States contains 4.6% of the world’s total population, but consumes two thirds of the world opioid supply.
12.5 million people, or 4.7% of the American population, aberrantly used prescription opioids in 2015. 4
1% of the U.S. population is addicted to opioids.
2015: 28,647 people died in the United States due to prescription opioid overdose
Prescription opioid use disorder is estimated to cost the American economy $53.4 billion per year.
Resurgence of heroin
Cheaper
Inappropriate weaning strategies from prescription opioids
Four fifths of heroin users report their initial exposure to opioids was to prescription opioids. 5
2007: Prescription opioid overdose responsible for more deaths than heroin and cocaine combined 6
1996–2006: Rate of prescription opioid use disorder increased by 167% 7
Rates continued to rise
Prescribing Patterns and Deaths
Statistics
Accidental deaths per year in United States 10 :
#1: Drug poisoning
40% of drug poisonings are due to opioid overdose.
#2: Automobile accidents
2015: United States—5.4% of high school seniors aberrantly used prescription opioids within the last year 11
40% stated that these drugs were easy to get.
2016: Canada—20.6% of grade 12 high school students aberrantly used opioid medication in the last year 12
70% obtained the medication from their own homes.
44 Americans die every day of a prescription overdose. 13
For every death there are:
10 treatment admissions for abuse
32 Emergency Department visits for misuse or abuse
130 people who abuse or are dependent
825 nonmedical users
Diversion
Illicitly obtained prescription opioids are often obtained from friends or family.
2006–2010: Street availability of prescription opioids increased
2010: 40% of Medicaid patients with opioid prescriptions had indicators of aberrant use or diversion 14
Surgeon’s role
Surgeons responsible for 9.8% of the total opioid prescriptions in the United States 15
Rates of opioid prescriptions to opioid naive patients after minor surgery increased between 2004–2012. 16
Surgeons may play a significant role in propagating the addiction crisis by exposing patients to potentially harmful and addictive opioid medications and contributing to the street supply of opioids.
Simple education interventions for patients to explain how to safely store and dispose of opioid medications can make a significant impact.
Led by the surgeon and a written handout or referral to a website which explains proper opioid storage and disposal
Proper Storage and Disposal
Opioids should be stored in a locked cabinet.
All unused medication should be returned to the pharmacy or destroyed once postoperative pain has resolved.
Surgery and Addiction
Patients who were opioid naive before surgery shown to have a significant chance of persistent postoperative opioid use. 17
Many patients continue to receive opioids chronically after initially receiving them for postoperative pain control.
Patients taking opioids chronically prior to surgery have an increased chance of still taking them 1 year later when compared with controls.
Opioids and Surgery
A 2016 study of elective hand surgery patients showed 13% were still taking opioids 90 days after surgery. 18
Another study found that 3.1% were still taking opioids at 90 days after major surgery. 19
Total knee arthroplasty: 1.4% chance of still taking opioids one year after surgery 20
Odds ratio of 5:1 when compared to nonoperated controls
Another study found that older patients (>66 years old) following low-risk surgery have a 44% increased likelihood of chronic use at 1 year compared with controls. 21
CAUTION: Surgery is a risk factor! There is a risk of persistent opioid use following exposure to opioid medications in the perioperative period, even in opioid naive patients.
Risk Factors for Opioid Abuse
History of substance use disorder
Comorbid psychological health conditions (i.e., anxiety, depression)
Male sex
Low socioeconomic status
Leftovers and Disposal
Elective hand surgery study (2012): 95% received opioids with average 30 doses 22
19 doses left over after acute pain resolution
Urology: 92% received no instructions on how to dispose of leftover opioids after surgery 23
67% had leftover opioids
91% of the patients with leftovers went on to keep them in an unlocked medicine cabinet 24
Oral surgery and pediatric surgery: similar to above
Thoracic and gynecological surgery: 83% had leftover opioid medication
71%–73% stored the leftovers unsafely
Senior Author Tip::
Since most people with prescription opioid use disorder get them from friends and family, it is reasonable to conclude that our postoperative analgesia prescription practices are making a significant contribution to the supply of illicit opioids.
Recommendations for Surgeons
Consider the risk that an individual patient may develop persistent opioid use and proceed to an opioid use disorder.
Consider the risk that medications prescribed postoperatively may end up diverted to nonmedical use and causing direct public health harm.
Identify risk factors:
Psychiatric illness
History of either aberrant substance use or diagnosed substance use disorder
Communicate to the patient in a nonjudgmental way so that they can exercise caution in taking prescribed medications.
Patients with an established or suspected substance use disorder should be referred to an addiction specialist preoperatively if possible. 25
Elective surgery in patients with established substance use disorders should not be performed until follow-up for substance use has been arranged.
Efforts should be made to explain and facilitate the use of nonopioid pain control.
Prescriptions should be limited to 20 doses of low potency, immediate release opioids unless circumstances clearly dictate otherwise. 26 , 27
Senior Author Tip::
We can make a major contribution by curbing opioid diversion in the perioperative period. We can partner with our anesthesia/pain colleagues to identify at-risk patients and prevent postoperative aberrant opioid use