8. Multimodal Analgesia for the Aesthetic Surgery Patient



10.1055/b-0038-163132

8. Multimodal Analgesia for the Aesthetic Surgery Patient

Girish P. Joshi, Jeffrey E. Janis

Understanding Multimodal Pain Management




  • “Prescription drug overdose is an epidemic in the United States. All too often, in far too many communities, the treatment is becoming the problem. 1



  • 80% of patients experience acute pain after surgery.



  • 75% of U.S. patients report surgical pain rated 7 or higher (scale of 1–10).



  • 59% of patients are concerned about postoperative pain. 2



Opioid Epidemic




  • November 2016: U.S. Surgeon General declares epidemic of addiction—public health crisis 3



  • United States contains 4.6% of the world’s total population, but consumes two thirds of the world opioid supply.



  • 12.5 million people, or 4.7% of the American population, aberrantly used prescription opioids in 2015. 4



  • 1% of the U.S. population is addicted to opioids.



  • 2015: 28,647 people died in the United States due to prescription opioid overdose



  • Prescription opioid use disorder is estimated to cost the American economy $53.4 billion per year.



  • Resurgence of heroin




    • Cheaper



    • Inappropriate weaning strategies from prescription opioids



  • Four fifths of heroin users report their initial exposure to opioids was to prescription opioids. 5



  • 2007: Prescription opioid overdose responsible for more deaths than heroin and cocaine combined 6



  • 1996–2006: Rate of prescription opioid use disorder increased by 167% 7




    • Rates continued to rise



Prescribing Patterns and Deaths




  • In patients with opioid prescriptions that overdose, the mortality rate increases with escalating dose. 8



  • Increases in opioid prescription rates have not resulted in improvement in patient disability or health outcome. 9



Statistics




  • Accidental deaths per year in United States 10 :




    • #1: Drug poisoning




      • 40% of drug poisonings are due to opioid overdose.



    • #2: Automobile accidents



    • 2015: United States—5.4% of high school seniors aberrantly used prescription opioids within the last year 11




      • 40% stated that these drugs were easy to get.



    • 2016: Canada—20.6% of grade 12 high school students aberrantly used opioid medication in the last year 12




      • 70% obtained the medication from their own homes.



    • 44 Americans die every day of a prescription overdose. 13




      • For every death there are:




        • 10 treatment admissions for abuse



        • 32 Emergency Department visits for misuse or abuse



        • 130 people who abuse or are dependent



        • 825 nonmedical users



Diversion




  • Illicitly obtained prescription opioids are often obtained from friends or family.



  • 2006–2010: Street availability of prescription opioids increased



  • 2010: 40% of Medicaid patients with opioid prescriptions had indicators of aberrant use or diversion 14



Surgeon’s role




  • Surgeons responsible for 9.8% of the total opioid prescriptions in the United States 15



  • Rates of opioid prescriptions to opioid naive patients after minor surgery increased between 2004–2012. 16



  • Surgeons may play a significant role in propagating the addiction crisis by exposing patients to potentially harmful and addictive opioid medications and contributing to the street supply of opioids.



  • Simple education interventions for patients to explain how to safely store and dispose of opioid medications can make a significant impact.



  • Led by the surgeon and a written handout or referral to a website which explains proper opioid storage and disposal



Proper Storage and Disposal




  • Opioids should be stored in a locked cabinet.



  • All unused medication should be returned to the pharmacy or destroyed once postoperative pain has resolved.



Surgery and Addiction




  • Patients who were opioid naive before surgery shown to have a significant chance of persistent postoperative opioid use. 17



  • Many patients continue to receive opioids chronically after initially receiving them for postoperative pain control.



  • Patients taking opioids chronically prior to surgery have an increased chance of still taking them 1 year later when compared with controls.



Opioids and Surgery




  • A 2016 study of elective hand surgery patients showed 13% were still taking opioids 90 days after surgery. 18



  • Another study found that 3.1% were still taking opioids at 90 days after major surgery. 19



  • Total knee arthroplasty: 1.4% chance of still taking opioids one year after surgery 20




    • Odds ratio of 5:1 when compared to nonoperated controls



    • Another study found that older patients (>66 years old) following low-risk surgery have a 44% increased likelihood of chronic use at 1 year compared with controls. 21



CAUTION: Surgery is a risk factor! There is a risk of persistent opioid use following exposure to opioid medications in the perioperative period, even in opioid naive patients.



Risk Factors for Opioid Abuse




  • History of substance use disorder



  • Comorbid psychological health conditions (i.e., anxiety, depression)



  • Male sex



  • Low socioeconomic status



Leftovers and Disposal




  • Elective hand surgery study (2012): 95% received opioids with average 30 doses 22



  • 19 doses left over after acute pain resolution



  • Urology: 92% received no instructions on how to dispose of leftover opioids after surgery 23




    • 67% had leftover opioids



    • 91% of the patients with leftovers went on to keep them in an unlocked medicine cabinet 24



  • Oral surgery and pediatric surgery: similar to above



  • Thoracic and gynecological surgery: 83% had leftover opioid medication




    • 71%–73% stored the leftovers unsafely



Senior Author Tip::


Since most people with prescription opioid use disorder get them from friends and family, it is reasonable to conclude that our postoperative analgesia prescription practices are making a significant contribution to the supply of illicit opioids.



Recommendations for Surgeons




  • Consider the risk that an individual patient may develop persistent opioid use and proceed to an opioid use disorder.



  • Consider the risk that medications prescribed postoperatively may end up diverted to nonmedical use and causing direct public health harm.



  • Identify risk factors:




    • Psychiatric illness



    • History of either aberrant substance use or diagnosed substance use disorder



    • Communicate to the patient in a nonjudgmental way so that they can exercise caution in taking prescribed medications.



  • Patients with an established or suspected substance use disorder should be referred to an addiction specialist preoperatively if possible. 25



  • Elective surgery in patients with established substance use disorders should not be performed until follow-up for substance use has been arranged.



  • Efforts should be made to explain and facilitate the use of nonopioid pain control.



  • Prescriptions should be limited to 20 doses of low potency, immediate release opioids unless circumstances clearly dictate otherwise. 26 , 27



Senior Author Tip::


We can make a major contribution by curbing opioid diversion in the perioperative period. We can partner with our anesthesia/pain colleagues to identify at-risk patients and prevent postoperative aberrant opioid use

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May 18, 2020 | Posted by in Aesthetic plastic surgery | Comments Off on 8. Multimodal Analgesia for the Aesthetic Surgery Patient

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