26 Microbiology in Atopic Eczema



A targeted topical antibiotic treatment in AE can be indicated in localized nummular eczema which often responds nicely to the combination of anti-inflammatory and antibacterial therapy. Suitable agents are mupirocin, fusidic acid and retapamulin. While in some countries there is a tendency to reserve mupirocin for eradication strategies in intensive care units and high-risk medical centres, others continue to use mupirocin as routine medication for infected skin disease. Fusidic acid is commonly used for cutaneous Staph. aureus infection but resistance is increasingly induced and in several areas, up to 50% show unresponsiveness [52]. Whether this in vitro resistance is also clinically relevant or whether it can be overcome by increased doses of fusidic acid remains a matter of debate. Retapamulin is a drug recently introduced for the treatment of cutaneous Staph. aureus infection which also shows excellent efficacy against streptococci for which the induction of resistance patterns has not yet been documented [53].


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Apr 26, 2016 | Posted by in Dermatology | Comments Off on 26 Microbiology in Atopic Eczema
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