Fig. 25.1
Survival of first renal grafts by donor source and HLA-match. Data from 2000–2009. ID-SIBL HLA-identical sibling, 1 Haplo 1 HLA haplo-identical living donor , 2 Haplo 2 HLA haplotype-mismatched living donor, DD 0 DR deceased donor, no HLA DR mismatch, DD 1–2 DR deceased donor, 1–2 HLA DR mismatches. (Data taken from: Norwegian Renal Registry 2010)
A further peculiarity of the Norwegian living donor program is that no patient with end-stage renal disease is put on the DD wait list before the possibility of a LD has been thoroughly evaluated. In other words, the DD wait list should be reserved for those patients who do not have the opportunity of receiving a LD graft. The availability of a sufficient amount of organs in Norway can only be made possible by the extensive use of LDs over time. Countries that traditionally do not use LDs will typically only be able to supply an organ to one third of those on the wait list. The Norwegian Ministry of Health has concluded that neither the Oviedo directive of the Council of Europe nor the organ directive of the European Union are legally in conflict with the Norwegian practise.2
After more than 7300 renal transplantations, of which over 2700 were with a kidney from a living donor, 72% of the Norwegian uremic population is successfully transplanted at any given time. This is the highest coverage compared to other countries. In 2011, the total transplantation rate per million was 60.4, including all kidney sources (Fig. 25.2).
Fig. 25.2
Renal transplantation and wait lists in 2011. Graft sources: DD deceased donor, LD living donor. Stars DD wait list. All data per million. (Newsletter Transplant 2012)
This is made possible by the high rate of LDs, averaging 37% over the years of the program. There is no age limit for transplantation or dialysis in Norway . Patients that are deemed unsuitable for transplantation at primary evaluation will, among other things, be offered heart-, aortic-, or carotid artery surgery where indicated, in order to make them eligible. Norway has a universal health care system. Dialysis also belongs to this public system and there are no private dialysis units in Norway . Recipients and potential LDs are processed at the 20 local nephrology centres in Norway and then referred to one national transplant centre for final approval and TX.
This one transplant centre, which handles all types of transplantations, covers the needs of 5 million Norwegians making it the largest centre of its kind in Scandinavia. All organ harvesting is also performed by the surgeons in this centre. Simple logistics lead to reduced costs and the second shortest average cold ischemia time in Scandinavia, despite long distances that need to be travelled for both organ retrieval and for patients coming to Oslo to receive their transplant.
Norway is a member and one of the founders of Scandiatransplant , which serves as a centralized computer system for all of Scandinavia and also controls the organ exchange within Scandinavia according to an agreed set of rules. This system gives supranational preference to children , patients with especially complicating antibodies and has also introduced a permissible mismatch program. Initially, the rate of exchange of organs among Scandinavian countries was approximately 25 %, giving special preference to HLA matching. Within recent years, the rate of exchange has been reduced to between 5–10 %. Less emphasis has been put on HLA matching and more on short cold ischemia time, which results in more organs being used locally and further acts as a motivating factor for the transplant teams. These guidelines are available on the Scandiatransplant homepage. In that some Scandinavian countries have a higher transplantation rate than others and while recipient wait lists also vary, a system to avoid an imbalance within Scandiatransplant has been developed, in which organs of comparable quality have to be returned to the donor country within half a year. Before this system was introduced, Norway was losing a significant amount of organs each year.
25.3 Number of Living Donors Has Not Kept up with the Increase of Uremic Patients in Norway
As can be seen in Fig. 25.3, there was an initial increase of LDs after the introduction of calcinurin inhibitor (CNI) in 1983–1984, but only marginal further increase in the years to follow, despite a steady increase in uremic patients in the same period (Fig. 25.4).
Fig. 25.3
Kidney transplantation in Norway with all available organ sources since the start of the national program. Data are given in number of patients per year from 1969–2012. In brackets: total number of patients. DD deceased donor, LD living donor. (Data taken from: Norwegian Renal Registry 2013)
Fig. 25.4
Patients with end-stage uraemia in Norway and treatment modalities since 1982. Data per million inhabitants. (Data taken from the Norwegian Renal Registry 2013)
This problem has been discussed repeatedly with local nephrologists and in 2007 our transplant centre introduced a LD coordinator that streamlines the process of finding suitable LDs for patients. From a surgical point of view, the introduction of laparoscopic donor nephrectomy in 1998, modified with hand assistance in 2005, should improve the LD situation further. It has led to less operative trauma, no intercostal nerve injuries, and faster postoperative recovery.3 The highest number of LDs was 104 registered in 2009 (incidence: 21.55 pmp), which proceeded to drop again so that LDs now only constitute 24 % of the total number of transplants (incidence in 2011: 14.7 pmp). The relatively low percentage of live donation at present is also caused by an increase in DDs, as will be discussed later.
25.4 Live Donation Is Not Practised Uniformlyin Norway
The use of LDs in the different regions in Norway varies with up to 50 % pmp, which could not readily be explained by demographic differences. The attitude of nephrologists and their centres towards live donation, the workload they are exposed to, or lack of systematic programs for the evaluation and processing of whole families are some probable explanations.
Thus in 2011, the Norwegian Directorate for Health appointed an expert group that developed a set of guidelines called: “Kidney Donation from Living Donor. Selection and Follow up of the Donor” (Nyredonasjon fra levende giver 2012).
A few of these guidelines are mentioned below and partially reflect already well-established routines:
Transplantation with a kidney from a LD should be the first choice for patients with end-stage renal failure and preferably be performed pre-emptively, if the patient is eligible.
Evaluation programs should be developed for both the registry of patients and potential donors in order to streamline the process.
The patients’ nephrologist is responsible for initiating this process, but should not be responsible for the evaluation of potential LDs.
If the patient permits, the donor’s doctor will actively approach first-degree family members for possible donation. Distant family members will only be considered if presented spontaneously and long-term friends will only be considered after the evaluation by a committee .
There should be a system of full compensation for the expenses the LD has had in connection with the donation process.
Life-long follow-up of LDs and a national registry of donor data should be continued and anonymous data contributed to a common Scandinavian living donor database at Scandiatransplant .Stay updated, free articles. Join our Telegram channel
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