Squamous Cell Carcinoma with Mucinous Metaplasia

Fig. 3.1

Squamous cell carcinoma with mucinous metaplasia. The tumor is characterized by an invasive SCC with large vacuolated cells scattered throughout the full epithelial thickness without glandular structures

Fig. 3.2

Squamous cell carcinoma with mucinous metaplasia. Large vacuolated cells are in intimate association with the atypical squamous component

Fig. 3.3

Squamous cell carcinoma with mucinous metaplasia. Large mucinous cells inside the squamous proliferation

Fig. 3.4

Squamous cell carcinoma with mucinous metaplasia. The presence of intracytoplasmic mucin is confirmed by positive staining for colloidal iron

Differential Diagnosis

Histopathologic differential diagnosis includes skin tumors exhibiting mucin-containing cells, mainly adenosquamous carcinoma and mucoepidermoid carcinoma. Both are characterized by the presence of glandular structures, invariably positive for CEA and CK7, while mucinous cells of SCCMM have been reported negative because they are keratinocytes.

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