Management strategy

Treatment of AGEP involves establishing the correct diagnosis (Table 8.1) coupled with the withdrawal of any implicated medication (Table 8.2). Pustular psoriasis is its main differential diagnosis. A comprehensive drug history and a personal or family history of psoriasis is therefore required.

Table 8.2

Drugs and other substances reported to have caused AGEP

Drugs

Antibiotics

Penicillins: amoxicillin, ampicillin, bacampicillin, pipemidic acid, piperacillin, propicillin, tazobactam Macrolides: azithromycin, erythromycin Quinolones: ciprofloxacin, norfloxacin, ofloxacin Tetracyclines: doxycycline, minocycline Cephalosporins: cefaclor, cefazolin, cefuroxime, cephalexin, cephradine Aminoglycosides: gentamicin, isepamicin sulfate, streptomycin Other antibiotics: chloramphenicol, clindamycin, co-trimoxazole, imipenem/cilastatin, lincomycin, metronidazole, nifuroxazide, sulfamethoxazole, teicoplanin, vancomycin, daptomycin, telavancin

NSAIDs

Celecoxib, etoricoxib, ibuprofen, naproxen, nimesulide, valdecoxib

ACE inhibitors

Captopril, enalapril

Calcium channel blockers

Nifedipine, nimodipine

Anticonvulsants

Carbamazepine, phenobarbital, phenytoin

Analgesia (opioid/non-opioid)

Acetaminophen, paracetamol, morphine, codeine, dextropropoxyphene

Anti-platelets

Aspirin, ticlopidine, clopidogrel

Benzodiazepines

Clobazam, nitrazepam, tetrazepam

Antimalarials

Chloroquine, hydroxychloroquine, proguanil, pyrimethamine

Antipsychotics

Clozapine, chlorpromazine

Antifungals

Amphotericin, fluconazole, itraconazole, nystatin, terbinafine

Antivirals

Lamivudine, lopinavir, ritonavir, zidovudine

Anti-TB drugs

Isoniazid, rifampicin

Proton pump inhibitors

Lansoprazole, omeprazole

Immunosuppressants

Azathioprine

Calcium channel blockers

Diltiazem

Antidepressants

Amoxapine, sertraline

Antihistamines

Clemastine, hydroxyzine

Beta agonists

Buphenine, fenoterol, nadolol

H2 receptor antagonists

Cimetidine, famotidine, ranitidine

Corticosteroids

Dexamethasone, methylprednisolone, prednisolone

Diuretics

Furosemide, hydrochlorothiazide

Anti-neoplastic drugs

Gefitinib, imatinib

Other drugs

Acetazolamide, allopurinol, bleomycin, carbimazole, cytarabine, disulfiram, eperisone hydrochloride, eprazinone, fluindione, icodextrin, interferon, metamizole, pentoxifylline, piperazine, bamifylline, propafenone, aprostadil, pseudoephidrine, psoralen + UVA, quinidine, salbutiamine, senna, simvastatin, sulfasalazine, terazosin, thalidomide, cadralazine, progestogens, dalteparin, carbutamide

Other substances

Chromium picolinate Diphenyl sulphone Contrast agents iohexol iopamidol Mercury Pneumococcal vaccine Pistacia lentiscus essential oil Only gold members can continue reading. Log In or Register to continue Share this: Click to share on Twitter (Opens in new window) Click to share on Facebook (Opens in new window) Related Related posts: Discoid lupus erythematosus Mucoceles Tinea capitis Herpes genitalis Necrolytic migratory erythema Nevoid basal cell carcinoma syndrome Stay updated, free articles. Join our Telegram channel Join Tags: Treatment of Skin Disease Comprehensive Therapeutic Strategies Aug 7, 2016 | Posted by admin in Dermatology | Comments Off on Acute generalized exanthematous pustulosis Full access? Get Clinical Tree Get Clinical Tree app for offline access Get Clinical Tree app for offline access