251 Yellow nail syndrome Robert L. Baran Evidence Levels: A Double-blind study B Clinical trial ≥ 20 subjects C Clinical trial < 20 subjects D Series ≥ 5 subjects E Anecdotal case reports The yellow nail syndrome (YNS) is an uncommon disorder of unknown etiology characterized by the triad of yellow nails, lymphedema, and respiratory tract involvement. This term was originally used to describe the association of slow-growing yellow nails with primary lymphedema. Pleural effusion was later recognized to be an additional sign of the syndrome. Since then, other respiratory conditions, such as bronchiectasis, sinusitis, bronchitis, and chronic respiratory infections have been associated with the disorder. Although all the three signs that classically characterize the triad of YNS do not occur in every patient, the presence of typical nail alterations should be considered an absolute requirement for the diagnosis. The complete triad is seen in 25% of patients, lymphedema in 40%, and pleural effusions in only 2% of patients with yellow nails. A variant of yellow nails can also be seen in HIV infection. Management Strategy Although YNS may resolve spontaneously, treatment is often sought by sufferers. The yellow nails are unsightly, discolored, hard, show transverse over-curvature, and are slow growing. Paronychia and onycholysis can be observed. Underlying diseases such as respiratory disorders, malignancy, infections, immunologic and hematologic abnormalities, endocrine, connective tissue and renal abnormalities, and miscellaneous disorders, including penicillamine therapy, should be sought. Titanium or titanium dioxide may cause YNS. Improvement of any underlying disorder (e.g., lymphedema) may also result in improvement of the nail plate. There are no large series or randomized trials in the treatment of YNS. Oral vitamin E has been used as monotherapy. The oral azole antifungals itraconazole and fluconazole have also been reported to be effective, both alone or in combination with vitamin E. The combination of fluconazole and vitamin E is currently the best treatment for curing the nail unit. This was confirmed by anecdotal reports that supplement our own findings. Matrix steroid injections have been successfully employed. Octreotide, zinc, and medium chain fatty acid triglyceride supplements as well as clarithromycin have been used in anecdotal reports. Attention to the diseases underlying yellow nails is mandatory but does not always result in resolution of the nail dystrophy. Therapies that effect resolution of the nail changes in yellow nails may have no effect on the associated pathology. Specific investigations Rule out nail fungal or Pseudomonas infection Complete blood count Urinalysis, proteinuria Immunoelectrophoresis Thyroid-stimulating hormone Serum rheumatoid factors Chemistry profile with blood creatinine Sinus and chest radiography ENT and pulmonary investigations Liver enzymes, alkaline phosphatases T and B cell deficiency Only gold members can continue reading. Log In or Register to continue Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window) Related Related posts: Cat scratch disease Hemangiomas Drug eruptions Erythropoietic protoporphyria Ichthyoses Nevoid basal cell carcinoma syndrome Stay updated, free articles. Join our Telegram channel Join Tags: Treatment of Skin Disease Comprehensive Therapeutic Strategies Aug 7, 2016 | Posted by admin in Dermatology | Comments Off on Yellow nail syndrome Full access? Get Clinical Tree
251 Yellow nail syndrome Robert L. Baran Evidence Levels: A Double-blind study B Clinical trial ≥ 20 subjects C Clinical trial < 20 subjects D Series ≥ 5 subjects E Anecdotal case reports The yellow nail syndrome (YNS) is an uncommon disorder of unknown etiology characterized by the triad of yellow nails, lymphedema, and respiratory tract involvement. This term was originally used to describe the association of slow-growing yellow nails with primary lymphedema. Pleural effusion was later recognized to be an additional sign of the syndrome. Since then, other respiratory conditions, such as bronchiectasis, sinusitis, bronchitis, and chronic respiratory infections have been associated with the disorder. Although all the three signs that classically characterize the triad of YNS do not occur in every patient, the presence of typical nail alterations should be considered an absolute requirement for the diagnosis. The complete triad is seen in 25% of patients, lymphedema in 40%, and pleural effusions in only 2% of patients with yellow nails. A variant of yellow nails can also be seen in HIV infection. Management Strategy Although YNS may resolve spontaneously, treatment is often sought by sufferers. The yellow nails are unsightly, discolored, hard, show transverse over-curvature, and are slow growing. Paronychia and onycholysis can be observed. Underlying diseases such as respiratory disorders, malignancy, infections, immunologic and hematologic abnormalities, endocrine, connective tissue and renal abnormalities, and miscellaneous disorders, including penicillamine therapy, should be sought. Titanium or titanium dioxide may cause YNS. Improvement of any underlying disorder (e.g., lymphedema) may also result in improvement of the nail plate. There are no large series or randomized trials in the treatment of YNS. Oral vitamin E has been used as monotherapy. The oral azole antifungals itraconazole and fluconazole have also been reported to be effective, both alone or in combination with vitamin E. The combination of fluconazole and vitamin E is currently the best treatment for curing the nail unit. This was confirmed by anecdotal reports that supplement our own findings. Matrix steroid injections have been successfully employed. Octreotide, zinc, and medium chain fatty acid triglyceride supplements as well as clarithromycin have been used in anecdotal reports. Attention to the diseases underlying yellow nails is mandatory but does not always result in resolution of the nail dystrophy. Therapies that effect resolution of the nail changes in yellow nails may have no effect on the associated pathology. Specific investigations Rule out nail fungal or Pseudomonas infection Complete blood count Urinalysis, proteinuria Immunoelectrophoresis Thyroid-stimulating hormone Serum rheumatoid factors Chemistry profile with blood creatinine Sinus and chest radiography ENT and pulmonary investigations Liver enzymes, alkaline phosphatases T and B cell deficiency Only gold members can continue reading. Log In or Register to continue Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window) Related Related posts: Cat scratch disease Hemangiomas Drug eruptions Erythropoietic protoporphyria Ichthyoses Nevoid basal cell carcinoma syndrome Stay updated, free articles. Join our Telegram channel Join Tags: Treatment of Skin Disease Comprehensive Therapeutic Strategies Aug 7, 2016 | Posted by admin in Dermatology | Comments Off on Yellow nail syndrome Full access? Get Clinical Tree