The final phase of wound healing involves scar maturation and tissue remodeling. This phase overlaps in time with the first two phases; it is said to begin with the production of the first granulation tissue. This phase extends for months and is complete when most of the collagen III and fibronectin have been replaced by mature type I collagen. In the final mature scar, the collagen fibers are oriented in large bundles running perpendicular to the basement membrane zone. The resulting scar has only 80% of the tensile strength of the uninjured skin.
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