Vesicles



Vesicles










Figure 10.1. Vesicle algorithm, excluding dermatoses (Table 10.1).








Table 10.1 Differential Diagnosis of Vesicular Bullous and Bullouslike Diseases of the Vulva





































































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Jun 15, 2016 | Posted by in Dermatology | Comments Off on Vesicles

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LOCATION OF VESICLE


DISEASE

SUBEPIDERMAL

INTRAEPIDERMAL
AND/OR
SUPRABASAL

ACANTHOLYSIS
OF SUPRABASAL
CELLS

SYSTEMIC
MANIFESTATION

IMMUNOFLUORESCENT
LOCALIZATION


Pemphigus vulgaris

No

Yes

Yes

Yes

IgG intercellular


Pemphigus vegetans

No

Yes

Yes

No

IgG intercellular


Pemphigoid (bullous) (cicatricial pemphigoid)

Yes

No

No

Yes
Localized scarring (sometimes debilitating)

IgG linear along basement membrane. IgA, IgM, C3, C5 may be in basement membrane


Herpes genitalis

Yes

No

No

Yes

C3, linear along basement membrane; IgG may also be present. IgM, IgA are rare


Polymorphic eruption of pregnancy, pruritic urticarial plaques and papules in pregnancy

Yes

No

No

Yes

Negative


Darier’s disease

No

Yes, dyskeratosis

Yes, 3+

Yes

Negative


Warty dyskeratoma

No

Yes

Yes

No

Negative


Erythema multiforme (Stevens-Johnson syndrome)

No

Yes, necrotic keratinocytes, hydropic degeneration of basal keratinocytes

No

Yes

IgM complement in and about superficial dermal vessels some cases


Hailey-Hailey