Treatment: Therapy needs to be individualized for each patient. Those with seizure disorders and CNS tumors require the expertise of a neurologist or neurosurgeon or both. Antiseizure medications are frequently required for prolonged periods. Routine ophthalmological examinations should be recommended to evaluate for the possibility of retinal astrocytic hamartomas (phakomas). Facial angiofibromas can be surgically removed by many means. Laser vaporization and more traditional surgical methods have been used to remove or lessen the appearance of these tumors. No therapy is required for the hypopigmented macules or the connective tissue nevi. All patients should be monitored routinely by their pediatrician for evaluation of developmental milestones and physical examinations.