Toxic epidermal necrolysis and Stevens–Johnson syndrome



Toxic epidermal necrolysis and Stevens–Johnson syndrome


Nicholas M. Craven and Daniel Creamer


Evidence Levels:  A Double-blind study  B Clinical trial ≥ 20 subjects  C Clinical trial < 20 subjects  D Series ≥ 5 subjects  E Anecdotal case reports


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Toxic epidermal necrolysis (TEN) and Stevens–Johnson syndrome (SJS) form a spectrum of rare, potentially life-threatening conditions manifesting widespread erythematous macules or atypical target lesions and severe erosions of mucous membranes. Confluence of cutaneous lesions leads to epidermal loss, which by definition involves less than 10% of total body surface area in SJS, 10–30% in overlap cases, and more than 30% in TEN. Complications develop similar to those seen after burns. In most cases TEN and SJS can be attributed to a drug reaction.



Management Strategy


The causative drug should be identified and discontinued. In general, drugs introduced in the 4 weeks before the onset of symptoms are usually responsible. If in doubt, all drugs should be stopped if possible.


The patient should be managed in a burns unit or appropriate high-dependency unit. Supportive therapy is directed at fluid replacement, maintaining a warm environment to reduce heat loss, topical antiseptic preparations, hydrocolloid dressings or skin substitutes to reduce colonization of the skin, and regular monitoring for sepsis. Fluid replacement requirements depend on the extent of involvement of the skin and mucous membranes, and may be 5–7 L in the first 24 hours. Peripheral lines are preferable to central lines, which increase the risk of sepsis. Nutritional support may require fine-bore nasogastric tube feeding until the oral mucosa has healed. All lines should be checked daily for signs of infection, changed at least every 3 days, and the tips of all discarded lines and catheters sent for culture. Antibiotics should not be given routinely as this may promote resistance. If signs of sepsis develop (rising or falling temperature, rigors, hypotension, fall in urine output, deterioration of respiratory status, diabetic control, or level of consciousness), initial antibiotic therapy can be guided by the results of swabs taken from the skin and mucous membranes. Necrolytic epidermis should be removed gently once it starts to fold over to reduce the risk of infection.


Ophthalmologic review should be obtained as soon as possible after diagnosis to minimize the risk of conjunctival scarring and blindness. Regular instillation of antiseptic eye drops and separation of newly forming synechiae are required. Oral and nasal debris should be cleaned regularly and an antiseptic mouthwash used several times a day.


Analgesia with opiates is often required, and care should be taken to monitor for respiratory depression. Respiratory failure may develop, requiring ventilation in an intensive care facility.


The use of systemic corticosteroids in the management of TEN and SJS remains controversial (see below). Several reports suggest that the use of corticosteroids increases morbidity and mortality, usually by increasing the risk of sepsis. Conversely, a number of case reports and short studies advocate the use of high-dose corticosteroids in the early stages of the evolution of these conditions. It is therefore possible that high-dose corticosteroids may prove beneficial in aborting further epithelial loss in patients with evolving SJS/TEN, but this has not yet been tested in a randomized controlled trial. Nevertheless, it is generally accepted that continuing administration of corticosteroids is counterproductive once extensive skin loss has occurred.


Several other potential disease-modifying treatments (intravenous immunoglobulin (IVIG), cyclosporine, pentoxifylline, plasmapheresis, cyclophosphamide) have been reported in small numbers of patients, but there is currently no strong evidence base for recommending any specific intervention other than supportive care.


Survivors of TEN and SJS and their close relatives should avoid exposure to the culprit drug and related compounds.



Specific investigations






Established TEN can usually be diagnosed clinically. Biopsy and immunofluorescence of an affected area of skin can exclude conditions such as staphylococcal scalded skin syndrome and paraneoplastic pemphigus. Histologic examination of the roof of a fresh blister (even on frozen section specimens) may be adequate to distinguish TEN from staphylococcal scalded skin syndrome.


Supportive care involves regular monitoring of full blood count, urea, creatinine, electrolytes (including calcium and phosphate), transaminases, glucose, blood gases, swabs from infected areas and flexures, blood and urine cultures, and urine output.









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Aug 7, 2016 | Posted by in Dermatology | Comments Off on Toxic epidermal necrolysis and Stevens–Johnson syndrome

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