Lupus pernio is the name given to the clinical findings of specific cutaneous sarcoid involvement of the nose and the rest of the face. This form of sarcoid is quite resistant to therapy, runs a more prolonged course, and is often difficult to treat. The skin findings are typically shiny brown-red plaques, papules, and nodules overlying the nose and other regions of the face. The involvement can become so severe as to cause disfigurement of the nose by shiny red-brown papules and plaques. Lupus pernio has nothing to do with the autoimmune disease lupus. Lupus pernio can be very difficult to treat, and systemic immune suppression is often required.
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