Chronic radiation dermatitis, in and of itself, does not require therapy unless the patient experiences severe tightness or hardness of the skin. In anecdotal reports, pentoxifylline has been successful in softening the areas of chronic radiation dermatitis. Topical moisturizers may help with the dryness. The most critical aspect is routine inspection of the area of chronic radiation dermatitis for the development of skin cancers, most commonly basal cell carcinoma and squamous cell carcinoma.
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