A Prospective Self-Controlled Phase II Study of Imiquimod 5% Cream in the Treatment of Infantile Hemangioma

Jiang CH, Hu XJ, Ma G, et al (Shanghai Jiaotong Univ, China) Pediatr Dermatol 28:259-266, 2011^§

Abstract

Imiquimod has been reported to be efficacious in the topical treatment of uncomplicated infantile hemangiomas (IH). However, due to the natural tendency of IH to involute spontaneously, prior uncontrolled efficacy and safety studies have been called into question. We conducted a prospective self-controlled phase II study of imiquimod initially applied to uncomplicated, proliferative superficial or mixed IHs treating half of each IH once every other night for 16 weeks, leaving the other half untreated. After 16 weeks, an independent dermatologist evaluated the color, area, and volume of each half of the hemangioma. Of the 44 patients treated, the total effective rate was 80% (n = 35), with an overall resolution rated as excellent or good rate in 39% of lesions (n

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