Pityriasis lichenoides chronica



Pityriasis lichenoides chronica


Alex Milligan and Graham A. Johnston


Evidence Levels:  A Double-blind study  B Clinical trial ≥ 20 subjects  C Clinical trial < 20 subjects  D Series ≥ 5 subjects  E Anecdotal case reports


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Pityriasis lichenoides chronica (PLC) typically consists of small erythematous papules, which may be purpuric. These develop a characteristic shiny mica-like scale attached to the center. They occur predominantly over the trunk and proximal limbs. As the name implies, PLC may persist for many years, though spontaneous resolution does occur. Patients should be warned that relapse is common and that recurrent courses of therapy may be required.


Anecdotally, PLC is said to run a more benign, self-limiting course in children, but more recently it has been shown that in children it is more likely to run an unremitting course, with greater lesional distribution, more dyspigmentation, and a poorer response to treatment. Some authors argue that there is an overlap with cutaneous lymphoma.




Management strategy


There are no controlled therapeutic trials for this condition, and case series are only small. In many therapeutic trials PLC has been grouped together with pityriasis lichenoides et varioliformis acuta (PLEVA) and management strategies are therefore often similar or interchangeable.


Topical corticosteroids are only reported as effective anecdotally in textbooks rather than in studies. They are often used with antihistamines to reduce pruritus, but they are not reported to affect the course of the disease.


The majority of reports describe benefits with UV therapy, and therefore either UV alone or with psoralen plus UVA (PUVA) therapy is recommended for all patients. The response appears to be unpredictable, however, and the total dose required is extremely variable.


Antibiotics appear to be more helpful in children, sometimes used in combination therapy.


For severe or refractory cases methotrexate, cyclosporine, and acitretin have all been described as effective in small numbers of patients.


For most treatment modalities, patients who have been described as improved have usually had fewer new lesions developing, a shortened disease course, and a greater time to relapse than untreated patients.



Specific investigations




Although a skin biopsy is usually unnecessary in clinically obvious cases, it may be useful before commencing aggressive systemic therapy.


An infective etiology is often suggested, but no pathogen has yet been implicated, though an association with toxoplasmosis has been described. These reports tend to come from endemic areas, and so investigation for a triggering infection is unnecessary in cases without evidence of specific infection.








First-line therapies






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Aug 7, 2016 | Posted by in Dermatology | Comments Off on Pityriasis lichenoides chronica

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