Molluscum contagiosum (MC) is an asymptomatic condition. Lesions are skin-colored, white, or slightly pink, flattened globose papules, 3 to 6 mm in diameter, many with a small central aperture or dell (Fig. 44-1). The surface is “semigloss,” pearl-like, and waxy. Lesions may occur singly or in groups. Exposed surfaces are favored, but no area is exempt. The groin and genitalia are commonly involved in sexually active persons. Lesions undergoing spontaneous resolution often become acutely inflamed. Facial involvement in adults usually indicates concomitant human immunodeficiency virus (HIV) infection. Lesions in these cases may become very large and run together. MC is a viral infection, common in children and young adults, and spreads by skin-to-skin contact.