Type of complication
Key nutrient(s)
Clinical findings
Supplementation
Metabolic bone disease
Vitamin D
Deficiency: rickets, osteomalacia
Oral (prevention): calcium 1,500 mg/day (band), 1,500–2,000 mg/day (gastric bypass), 1,800–2,400 mg/day (DS)
Calcium (magnesium, phosphorus, vitamin K)
Toxicity: hypercalcemia, anorexia, nausea, abdominal pain, lethargy, weight loss, polyuria, constipation, confusion, coma; cardiac and renal damage
Oral (treatment): vitamin D3 2,000 IU/day
Oral (treatment/severe deficiency): vitamin D2 50–150,000 IU/day
Neurologic
Thiamin (vitamin B 1)
Deficiency (thiamin): poor appetite, confusion, weakness, anorexia, tachycardia, muscle cramps, paresthesia, symmetric motor and sensory neuropathy
Oral (treatment): thiamin 10–100 mgs 1–3×/day
Vitamin B12
Deficiency (B12): glossitis, weakness, pallor, depression, peripheral neuropathy, paresthesia, dementia
IV (treatment): thiamin 100–500 mgs/day 1–3×/day
Copper
Deficiency (copper): leukopenia, anemia, hypopigmentation of hair
Oral/sublingual: vitamin B12 250–350 μ(mu)g 1–2×/day or 1,000 μg/month
Toxicity (copper): anemia, nausea, vomiting, muscle aches, abdominal pain
Intranasal: vitamin B12 500 μ(mu)g/week
IM: vitamin B12 1,000 μ(mu)g/month or 1,000–3,000 μ(mu)g every 6–12 months
Nutritional anemia
Iron
Deficiency (iron): fatigue, irritability, tachycardia, palpitations, cheilosis, koilonychia, pica
Oral (treatment): ferrous sulfate, fumarate, or gluconate, 320 mg (with vitamin C) 2×/day between meals
Vitamin B12
Toxicity (iron): nausea, abdominal pain, vomiting; renal, cardiac and hepatic damage (severe)
Parenteral: (treatment/severe deficiency) iron dextran, ferric gluconate, or ferric sucrose
Folic acid (copper, vitamin A, selenium)
Deficiency (B12): glossitis, weakness, pallor, depression, peripheral neuropathy, paresthesia, dementia
Oral/sublingual: vitamin B12 250–350 μ(mu)g 1–2×/day or 1,000 μ(mu)g/month
Deficiency (folic acid): glossitis, weakness, diarrhea, fatigue, depression, confusion, irritability, neural tube defects during pregnancy
Intranasal: vitamin B12 500 μ(mu)g/week
IM: vitamin B12 1,000 μ(mu)g/month or 1,000–3,000 μ(mu)g every 6–12 months
Oral (prevention): folate 400–800 mcg/day
Oral (treatment): copper 6 mg (elemental)/day × 1 week, then 4 mg/day the next week, and 2 mg daily thereafter
Ocular
Vitamin A
Deficiency: night blindness, xerosis and hyperkeratinization of the skin, Bitot’s spots (early), keratomalacia, blindness (late), loss of taste, fatigue, poor bone growth, weak tooth enamel
Oral: vitamin A 5,000–10,000 IU/day until serum levels normalize; up to 65,000 IU/day for 2–3 months for resolution of symptoms
Beta carotene, retinol
Toxicity: gingivitis, cheilitis, erythema, desquamation, dry skin, bone fractures, blurred vision, hair loss; pseudotumor cerebri and hepatic failure (severe) (beta carotene form rarely associated w/ toxicity)
Parenteral: (treatment/severe deficiency) vitamin A 25,000 IU/day
Protein malnutrition
Protein
Deficiency: fatigue, weakness, hair loss, edema, temporal wasting
Oral: high-quality liquid protein formula; feeding tube or parenteral (treatment/severe deficiency)
It is worth mentioning that patients that have mechanical or metabolic complications that result in intractable vomiting might develop over time food aversion that by itself perpetuates emesis. Psychological or psychiatric intervention to rule out this disorder is imperative after all other potential causes have been ruled out.
Conclusion
Supplement Noncompliance
Poor clinical follow-up often equates to poor compliance with routine blood work and micronutrient supplements. Forgetfulness, poor education about the need for lifelong supplementation, or ironically deficiency states themselves (such as memory loss from vitamin B12 deficiency) may contribute. Patients may believe that being at a healthy weight, and/or eating larger portions of food, months and years after surgery, translates to not needing to take supplements. Alternatively, they may believe that regaining weight after surgery means additional vitamins and minerals are no longer needed. Many are knowledgeable regarding the importance of supplementation, but find the frequency of taking pills hard to sustain, have difficulty swallowing (sometimes large) pills, or have run into financial difficulties and no longer purchase supplements. Methods of managing these patients and increasing compliance include routinely reaching out via email, telephone, or postcards to remind them of annual visits, blood work that is due, support group meeting schedules, and publications from your practice or third-party organizations. It is helpful to reinforce to patients that long-term follow-up with your office and attending support groups are predictive of their success [15, 17]. Another way to increase compliance is to educate patients on alternative ways to take supplements. Some patients prefer crushing or dissolving pills, selecting chewable, liquid, or powdered (or even injectable) forms, to swallowing them on a daily basis, but some are unaware of these options.