Treatment: Therapy is based on the cause of the leukocytoclastic vasculitis. New offending medications should be withdrawn and replaced with substitutes of a different class. Infections need to be thoroughly treated. The use of topical high-potency corticosteroids is helpful in some cases, and oral steroids may be used in medication-induced leukocytoclastic vasculitis. In cases of infection-induced vasculitis, prednisone should be reserved until after the infection has been properly treated. Idiopathic vasculitis is treated with oral steroids, and often a search for an infection or other cause is undertaken. A thorough history and physical examination are needed, as well as some screening laboratory tests. Laboratory testing usually is not helpful unless the history or review of symptoms points in a particular direction. If patients are suffering from more than just very mild systemic symptoms, an evaluation should be done to rule out the more serious forms of vasculitis.
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