Treatment: Surgical excision of the solitary form of leiomyoma is curative. Multiple cutaneous leiomyomatosis can be treated with a number of medications to help control the discomfort and pain. Use of α₁-adrenergic receptor blockers has been reported most frequently. Doxazosin and phenoxybenzamine have both been successful. Calcium channel blockers such as nifedipine have also been successful anecdotally. Gabapentin and botulinum toxin have been reported to help. Surgical excision is warranted for any lesion that is painful and not responding to therapy. Patients with multiple cutaneous leiomyomas should be evaluated for the genetic defect in the fumarate hydratase protein and should have appropriate screening for kidney disease.

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