Multisystem disease is treated in myriad manners, depending on the burden of disease, the systemic involvement, and the patient’s symptoms. The disease can be difficult to treat, and systemic chemotherapies are the mainstay of treatment. Vinblastine- or etoposide-based regimens are most commonly used as first-line therapy. Some refractory disease has been treated with ablative chemotherapy and subsequent bone marrow transplantation.
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