Treatment: No therapy is required for most cases. A keratolytic moisturizer or humectant moisturizer works well. These include lactic acid– and salicylic acid–based moisturizers. After discontinuation, however, the rash of keratosis pilaris returns over a period of a few weeks to months. Many other therapies have been used. Vitamin A derivatives (e.g., tretinoin) are among the more commonly used prescription medications. The cream is applied daily and has been successful in removing the redness and hyperkeratosis.