No specific symptoms are associated with Kaposi’s sarcoma (KS). KS occurs in two forms—one related to aging (classic form) and another due to immune suppression (acquired or iatrogenic). The classic form most often occurs on the legs and consists of violaceous patches, papules, or plaques (Fig. 60-1). This form is more prevalent in persons of Mediterranean and/or Jewish ancestry. KS associated with immunosuppression occurs in any site and is often mistaken for a simple ecchymosis. KS is a vascular neoplasm associated with human herpesvirus-8 infection.