Wound Healing and Infection in Surgery: The Pathophysiological Impact of Smoking, Smoking Cessation, and Nicotine Replacement Therapy: A Systematic Review

Sørensen LT (Univ of Copenhagen, Denmark) Ann Surg 255:1069-1079, 2012^§

Abstract

Objective

The aim was to clarify how smoking and nicotine affects wound healing processes and to establish if smoking cessation and nicotine replacement therapy reverse the mechanisms involved.

Background

Smoking is a recognized risk factor for healing complications after surgery, but the pathophysiological mechanisms remain largely unknown.

Methods

Pathophysiological studies addressing smoking and wound healing were identified through electronic databases (PubMed, EMBASE) and by hand-search of articles’ bibliography. Of the 1460 citations identified, 325 articles were retained following title and abstract reviews. In total, 177 articles were included and systematically reviewed.

Results

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