Topical corticosteroid is a milestone that revolutionized the management of several types of dermatoses. The journey which started in 1930 with the adrenal extracts, finally found its track in the road of topical dermatoses in 1952 with hydrocortisone. The journey always remained challenging. This journey was mostly by manipulation of the steroid molecule to produce compounds with greater lipophilicity, fewer mineralocorticoid properties and high potency. However, addition of new members in the regiment was encouraging, and several new topical agents were designed over the years. In the 1960s, the world witnessed the emergence of the high-potency fluorinated agents like triamcinolone, flurandrenolone, flumethasone or betamethasone. Betamethasone was used topically in for the first time in 1964. It was a discovery which remained as a milestone in the dermatology practice. Unfortunately, adverse drug reactions occur by the same mechanism which resulted in the action of the topical corticosteroids. On the other hand, systemic absorption of the topical agents is another challenge which needs to be addressed. Unless these limitations are overcome, the painstaking journey of development of the topical corticosteroids is yet to be over. Therefore, the world will wait to see the better tomorrows with newer topical agents which will virtually eliminate the risk of systemic absorption and adverse effects one fine morning!