Treatment: Treatment is primarily symptomatic. One must pursue the possibility of an underlying disorder. Erythema nodosum induced by medications or pregnancy resolves spontaneously once the medication is withdrawn or after delivery. Those cases associated with an underlying infection, malignancy, or inflammatory bowel disease may be longer lasting and may show a waxing and waning course. Topical corticosteroids, compression stockings, elevation, and nonsteroidal antiinflammatory agents are first-line therapies. Severe cases can be treated with a short course of prednisone. Supersaturated potassium iodide and colchicine have also been reported to be used successfully.