Treatment: The main goal of therapy is to return the triglyceride level back to a normal range. Medications that can cause hypertriglyceridemia need to be discontinued. Underlying diabetes needs to be treated aggressively to get better control of glucose metabolism and insulin requirements. Those patients with familial causes need to institute dietary changes (to avoid medium-chain triglycerides), increase their activity level, and take triglyceride-lowering medications. These medications can be used for all causes of hypertriglyceridemia. The medications most commonly used to lower triglyceride levels are fenofibrate and gemfibrozil.