The Effect of Neoadjuvant versus Adjuvant Irradiation on Microvascular Free Flap Reconstruction in Sarcoma Patients

Chao AH, Chang DW, Shuaib SW, et al (The Univ of Texas MD Anderson Cancer Ctr, Houston) Plast Reconstr Surg 129:675-682, 2012^§

Abstract

Background

Sarcoma patients often require radiation therapy in addition to surgical resection. Although neoadjuvant irradiation possesses advantages over adjuvant irradiation related to smaller doses and field sizes, existing studies suggest adverse effects on wound healing and possibly microvascular free flap success. Conversely, microvascular reconstruction may counteract some of the negative effects of irradiation by replacing irradiated tissue with well-vascularized unirradiated tissue from a distant site.

Methods

A review of sarcoma patients who underwent resection, microsurgical reconstruction, and either neoadjuvant or adjuvant irradiation was performed.

Results

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