effect of hyperbaric oxygen therapy on the survival of random pattern skin flaps in nicotine-treated rats


The effect of hyperbaric oxygen therapy on the survival of random pattern skin flaps in nicotine-treated rats


Selçuk CT, Kuvat SV, Bozkurt M, et al (Dicle Univ Med Faculty, Diyarbakir, Turkey; Reconstructive and Aesthetic Surgery, Istanbul, Turkey; et al) J Plast Reconstr Aesthet Surg 65:489-493, 2012§



J. Boehmler, MD



Evidence Ranking


A



Expert Rating


2



Abstract


Previous studies have shown that nicotine increases the risk of necrosis in skin flaps. We investigated the effect of hyperbaric oxygen (HBO2) treatment on the survival of random skin flaps in nicotine-treated rats.


Thirty-two Sprague–Dawley rats were divided into four groups with eight rats in each group. Group 1 (n = 8) was the control, group 2 (n = 8) received HBO2 treatment without being exposed to nicotine, group 3 (n = 8) received nicotine and group 4 (n = 8) received HBO2 treatment with exposure to nicotine. The rats in the nicotine-treated groups were prepared by treating them with nicotine for 28 days. At the end of the 28th day, standard McFarlane-type random skin flaps were lifted from the backs of all the rats. In groups 2 and 4, HBO2 treatment started at the 30th min following the surgery and continued once a day for 7 days.

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May 5, 2016 | Posted by in Aesthetic plastic surgery | Comments Off on effect of hyperbaric oxygen therapy on the survival of random pattern skin flaps in nicotine-treated rats

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