The eccrine porocarcinoma is very uncommon; histologically, it is a tumor that is poorly circumscribed and often found in conjunction with an eccrine poroma. Cells with multiple large nuclei and multiple mitoses help make the diagnosis. Eccrine porocarcinomas can mimic metastatic adenocarcinomas, and immunohistochemical staining is required to make certain of the diagnosis.
Treatment: Although they are benign tumors, eccrine poromas often are located on the sole or palm and require removal from a functional standpoint. Surgical excision with a small (1-2 mm), conservative margin is curative. The recurrence rate is very low after surgical excision. Electrodesiccation and curettage has been used successfully. Eccrine porocarcinomas require surgical excision and close clinical follow-up. Chemotherapy is reserved for cases of metastatic disease. The role of sentinel lymph node sampling in these tumors has yet to be defined.
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