Developmental Anomalies


Developmental Anomalies

Developmental anomalies are a diverse group of congenital disorders that result from faulty in utero morphogenesis. When they affect the skin, developmental anomalies can range in severity from isolated minor physical findings to potentially life-threatening conditions or cutaneous signs of significant extracutaneous defects.

Midline Lesions Overlying the Spine

Midline cutaneous lesions serve as a valuable marker for ‘occult’ spinal dysraphism and are present in ~80% of affected individuals (most of whom have >1 type of skin lesion), compared to <3% of the general population; shallow coccygeal dimples and deep gluteal clefts, which are considered as normal variants, occur in an additional 4% of infants.

Skin lesions associated with spinal dysraphism are presented in Table 53.2 and Fig. 53.7.

Table 53.2

Skin lesions of the spinal axis associated with dysraphism.

The presence of two or more types of lesions increases the risk of a spinal anomaly.

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Apr 22, 2016 | Posted by in Dermatology | Comments Off on Developmental Anomalies

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Lesion Features
Hypertrichosis A V-shaped patch of long, coarse or silky hair (see Fig. 53.7A,B); ‘faun tail’
Lipomas Soft subcutaneous mass, asymmetric buttocks, curved gluteal cleft (see Fig. 53.7C); most common sign of spinal dysraphism