Treatment: Therapy for skin myxomas includes observation or excision of individual lesions. Lentigines and blue nevi can be removed for cosmetic purposes. Atrial myxomas are the leading cause of morbidity and mortality, and they require removal by cardiothoracic surgery. Patients need to be monitored by cardiology and endocrinology specialists for their entire lifetime. Routine screening evaluations of the heart, pituitary, adrenal gland, and testicles must be performed.