Café-au-lait macules (CALMs)

Numerous CALMs in a child with NF1.

Axillary freckling in child with NF1.

CLINICAL FEATURES

CALMs are tan oval macules with distinct borders. Multiple CALMs are an early sign of neurofibromatosis type 1 (NF1). CALMs are rarely present at birth but increase in number with age. One-fourth of healthy teens have at least one CALM, and having two is also common.

Six or more CALMs greater than 0.5 cm

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