Tissue-Engineered Breast Reconstruction: Bridging the Gap Toward Large-Volume Tissue Engineering in Humans

Findlay MW, Dolderer JH, Trost N, et al (O’Brien Institute, Melbourne, Australia; St Vincent’s Hosp Melbourne, Australia; Univ of Melbourne, Victoria, Australia) Plast Reconstr Surg 128:1206-1215, 2011^§

Abstract

Background

Use of autologous tissue is ideal in breast reconstruction; however, insufficient donor tissue and surgical and donor-site morbidity all limit its use. Tissue engineering could provide replacement tissue, but only if vascularization of large tissue volumes is achievable. The authors sought to upscale their small-animal adipose tissue-engineering models to produce large volumes of tissue in a large animal (i.e., pig).

Methods

Bilateral large-volume (78.5 ml) chambers were inserted subcutaneously in the groin enclosing a fat flap (5 ml) based on the superficial circumflex iliac pedicle for 6 (n = 4), 12 (n = 1), and 22 weeks (n = 2). Right chambers included a poly (l-lactide-co-glycolide) sponge. Other pedicle configurations, including a vascular pedicle alone (n = 2) or in combination with muscle (n = 2) or a free fat graft (n

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