Treatment: After biopsy has ruled out an invasive component to this tumor, the main treatment of bowenoid papulosis is to clinically remove the areas of involvement. The importance of decreasing HPV transmission to the patient’s sexual partners must be addressed. Condoms should be used at all times to help decrease the risk of transmission. Topical therapy with 5-fluorouracil or imiquimod has been advocated as the first-line therapy. Surgical treatment with electrocautery, cryotherapy, or laser ablation has also been reported to be successful. Both patients and their sexual partners should be seen for routine follow-up examinations.