Chapter 2 Acanthotic seborrheic keratoses are composed of broad sheets of cells with intervening horn cysts or pseudohorn cysts. Horn cysts are completely encased within the acanthoma, whereas pseudohorn cysts open to the surface. Like other seborrheic keratoses, they may become irritated or inflamed. The tall stacked stratum corneum is typically much thicker than the epidermis. As in other forms of seborrheic keratosis, the keratin has a loose lamellar “shredded-wheat” appearance unless the lesion has become irritated or inflamed. Papillomatosis is characteristic, but variable in degree. Horn cysts are inconspicuous or absent. Clonal seborrheic keratosis is characterized by islands of small keratinocytes with uniform bland nuclei. The nests are embedded within the epidermis. Sometimes, the nests are large enough that the normal epidermis is reduced to thin strands separating the large nests. Horn cysts are usually absent. The nests may demonstrate pigment. There may be squamous eddies (irritated seborrheic keratosis), lymphocytes (inflamed seborrheic keratosis), or both. In contrast to Bowen’s disease, the cells are uniform and atypia is absent. In contrast to hidroacanthoma simplex, no ducts are present within the clones.
Benign tumors and cysts of the epidermis
Benign acanthomas
Seborrheic keratoses
Acanthotic seborrheic keratosis
Hyperkeratotic seborrheic keratosis
Clonal seborrheic keratosis