97
B-Cell Lymphomas of the Skin
PCBCL
• B-cell lineage is identified by the presence of CD20 and CD79a and the absence of CD3 markers.
• Usually affects older adults and males > females.
• Once the diagnosis of a B-cell lymphoma in the skin has been made, complete staging (Table 97.1) is recommended to distinguish between primary and secondary cutaneous lymphoma.
Table 97.1
Recommended staging evaluation for patients with confirmed diagnosis of B-cell lymphoma involving the skin.
LDH, lactate dehydrogenase; CT, computerized tomography; PET, positron emission tomography; HIV, human immunodeficiency virus; PCR, polymerase chain reaction.
• The new World Health Organization–European Organization for Research and Treatment of Cancer (WHO–EORTC) classification provides the basis for a consistent classification of patients and divides PCBCL into four major types (Table 97.2).
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