TRAPS is inherited in an autosomal dominant pattern and also can occur sporadically. Patients develop attacks early in childhood, which consist of fever, abdominal pain, conjunctivitis, arthralgias, and migratory myalgias. The attacks last longer than in the other autoinflammatory syndromes. Each attack may last from days to weeks, with frequent recurrences. Attacks may be precipitated by varying amounts of stress, both physical and emotional. Again, the development of renal amyloidosis in adulthood has profound effects on the prognosis and is estimated to occur in 10% of TRAPS patients. Skin findings are characteristic and consist of migratory, pink to red patches and macules. Periorbital swelling may be prominent.
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