Histology: All angiosarcomas share the same pathological features. The tumor lobules are poorly circumscribed and have an infiltrative growth pattern. They contain large amounts of vascular tissue in a disorganized arrangement. The lining of the vascular spaces contains atypical-appearing endothelial cells. Mitoses are frequently encountered, as are intracytoplasmic lumina. The same tumor can contain well and poorly differentiated regions.
Treatment: The standard treatment is wide local excision with the goal of obtaining clear margins. This is usually followed by postoperative radiation therapy. The 5-year survival rate is low (15%-20%). Tumors that are metastatic or nonoperable can be treated palliatively with various chemotherapeutic regimens. The median survival time in these cases is 3 to 6 months.
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