Abuse of Topical Corticosteroid as Cosmetic Cream: A Social Background of Steroid Dermatitis




© Springer Nature Singapore Pte Ltd. 2018
Koushik Lahiri (ed.)A Treatise on Topical Corticosteroids in Dermatologyhttps://doi.org/10.1007/978-981-10-4609-4_12


12. Abuse of Topical Corticosteroid as Cosmetic Cream: A Social Background of Steroid Dermatitis



Sanjay K. Rathi  and Paschal D’Souza 


(1)
Consultant Dermatologist, 143, Hill Cart Road, Siliguri, 734 001, West Bengal, India

(2)
Department of Dermatology, ESIC-PGIMSR, New Delhi, India

 



 

Sanjay K. Rathi (Corresponding author)



 

Paschal D’Souza



Abstract

Topical corticosteroids (TC) are used frequently for approved and non-approved indications in dermatology. This improper use and misuse has now also spilled over to TC being used for cosmetic purpose as fairness cream which is accepted fairly well in the society with recommendations originating from relatives, friends, neighbour, beautician, chemists, etc. This addiction and abuse of TC particularly on the face as cosmetic cream has led to development of unique ‘steroid dermatitis’, manifesting as perioral, diffuse, centrofacial and malar variants. Rapid effect, cheap, easy availability, ignorance of adverse effects, inappropriate marketing and society’s attitude towards fair skin colour are few reasons which tempt patients (mostly females) to start TC as cosmetic creams. TC-damaged face is really difficult to treat which therefore calls for measures preventing its development in the first place. Proper education regarding TC needs to be imparted at individual and community levels using all available resources to prevent its misuse as cosmetic creams. Administrative, regulatory and enforcement measures need to be strengthened to ensure that TC are only available through proper channel of prescription by authorised specialists.


Keywords
Topical corticosteroidAbuseCosmetic creamSteroid dermatitisSocial backgroundCauseManagement



Learning Points




  1. 1.


    Topical corticosteroid abuse as a cosmetic in the social context has its genesis in the elevation of status of some topical corticosteroids as beautifying creams which are apparently effective, have instantaneous results and are cheap, easily available, socially acceptable and popular.

     

  2. 2.


    This has led to the development of unique ‘steroid dermatitis’ due to the so-called steroid addiction and inability to withdraw the drug on account of extreme discomfort in attempting to do so.

     


12.1 Introduction


Since hydrocortisone was first introduced in 1951 and modifications over subsequent years of the primary molecule led to birth of new molecules with different potencies, efficacy and safety profile, dermato-therapeutics has undergone a tremendous revolution [1]. It has never been easier to treat a variety of dermatoses in such an effective manner and bring quick relief to patients suffering with them for months or several years. With prudence over time, the ethical dermatologist used it mainly for non-infective inflammatory conditions and as per certain guidelines [2]. Sadly, TC started being used for improper indications like acne, tinea, urticaria, non-specific pruritus, etc. by general practitioners (GP), registered medical practitioners (RMP), practitioners of alternate medicine, quacks, chemists and homemade doctors (parents, siblings, neighbours) [3]. Due to the prolonged or improper use of TC in approved and non-approved indications, some well-defined adverse effects of TC came to be known [4]. Simultaneously, there came a time when the use of these wonder drugs spilled into the cosmetic realm where some of the pharmacological and adverse effects of TC, e.g. vasoconstrictive and melanopenic effects, were perceived as boom for people hungry to look fair. This was more apparent specially in those of brown and dark races. Here was a situation where people of ‘no skin disease’ preferred to use TC over safe cosmetic creams to look fair or hide their blemishes. With this, a new dermatosis emerged due to long and improper use and for obvious reasons was mainly confined to the face. This dermatosis was named variously by different workers: light-sensitive seborrheic dermatitis, perioral dermatitis, rosea-like dermatitis, steroid rosacea, steroid dermatitis resembling rosacea, steroid-induced rosacea-like dermatitis, topical corticosteroid-induced rosacea-like dermatitis (TCIRD) and topical steroid-dependent face (TSDF) [514].


12.2 Epidemiology of TC Abuse as a Cosmetic


Abuse of TC as a cosmetic probably must be as old as the discovery of TC itself. Almost all dermatologist encountered patients revealing inappropriate use of TC but very few documented it and brought it up to the level of published literature [912, 15, 16]. It is only in the last two decades when it has assumed epidemic proportion and unusual steroid induced difficult to treat dermatitis started appearing, that the community has been jolted to actively survey prevalence of the problem in the society resulting in many recent studies to this effect [8, 14, 1720].

The phenomenon of TC abuse as a cosmetic is universal with reports appearing across the world [2126]. Due to the society’s increased preference for fairness which is a commonplace in Caucasian American and European skin, the abuse appears to be more in races that have constitutive brown or black skin. Although generally not mentioned, one study found that frequency of patients with TC-related adverse effects amounted to 5.63% of all the dermatology patients seen during the period [26]. It is seen more often in the younger age group of 21–30 years, probably because they are socially more active [19, 2427]. A strong female preponderance is seen in almost all studies. This may be because of their quest to look pretty and because in our society ‘a fair bride’ is always preferable. Most studies have found an urban preponderance though some reported it more in rural areas [24, 27]. Individuals are usually of poor socioeconomic background with surprisingly good educational level [25, 26, 28]. Majority of them were students or housewives [2428]. The problem of TC abuse as a cosmetic is not limited to lay people alone. In a study, 31% of nursing students were using face creams containing steroid alone or in combination, of which 64% were of potent category [29].

Among the TC involved, betamethasone valerate appears to be the commonest followed variably by different steroid + antibacterial + antifungal combinations, clobetasol propionate, fluocinolone acetonide and mometasone furoate creams [8, 14, 19, 2428]. It is a fact that there is hardly any household in India which has not heard of the brand name Betnovate cream (containing betamethasone valerate) by Glaxo. Duration of use of TC was usually for less than 12 months in most studies before patient presented with evidence of steroid dermatitis though TC applications up to 20 years have been documented [14]. Steroid dermatitis usually starts appearing within 6 months of continuous TC abuse [8].

Among the common cosmetic reasons for the use of TC are to look fair and beautiful; for acne, blemishes, suntan and dry skin; and as general skin care purpose [8, 14, 19, 2428]. The suggestion to start TC as cosmetic cream comes from many quarters including friends, relatives, chemists and beauticians.


12.3 Reason for Popularity of TC as Cosmetic Cream


Among the factors responsible for the commonplace use of TC as a cosmetic cream by so many individuals are:


  1. 1.


    Rapid effect: Most patients cite the instant magical effect of TC as one of the commonest reasons for its use in their common day-to-day perceived problems on their skin [8, 14]. This is also the reason of their repetitive and prolonged use in many instances which ultimately bring them to the dermatologist with frank steroid dermatitis.

     

  2. 2.


    Cheap: Compared to the regular standard fairness and beauty creams in the market, some of the brands regularly used by the patients are very cheap as they come under government DPCO (Drug Control Price Order) [1]. A simple example is of a 20 gm of betamethasone valerate cream which would cost 18.63 rupees compared to a Fair & Lovely brand of cosmetic cream containing niacinamide which costs around 45 rupees for 25 gm. This cost comparison may not always be in favour of TC particularly when it comes to TC containing triple combinations which can be costlier.

     

  3. 3.


    Easy availability: As of today, TC are available for the asking in both cities and villages. The disturbing part is that even the most potent TC like clobetasol propionate especially in combination creams are available over the counter and are among the top-selling brands in India [30].

     

  4. 4.


    Ignorance about adverse effects of TC: Most patients are blissfully unaware of the adverse effects of TC abuse [26]. Even when they start noticing the adverse effects of TC on their skin, they continue to use them due to the rebound phenomenon they experience on attempting to withdraw the drug [8]. This cycle continues for some time before they are forced to ask for help from a specialist.

     

  5. 5.


    Inappropriate counselling by healthcare workers when prescribing TC for appropriate indications: Some of the social problem of TC abuse is because of failure of the dermatologist to explain in a balanced way the potential dangers of not following the advice given when patients are being treated for proper steroid-responsive dermatoses [31]. Patients tend to self-medicate frequently once they get good response and don’t bother to return to their doctor. They frequently experiment with TC for imagined similar-looking skin conditions including on the face. The vasoconstrictive, anti-inflammatory and melanopenic effects are noticed by them and used later to lighten their skin for cosmetic use.

     

  6. 6.


    Inappropriate marketing strategies of pharmaceutical firms: A recent report appeared of illegal sale of steroid-laden creams by Himachal Pradesh-based manufacturer Torque Pharma [32]. The two products U-B Fair for men and No Scars cream for women contained TC like fluocinolone acetonide and mometasone along with skin bleaching agents. Maharashtra FDA seized them on the premise that products have been advertised as beauty treatments in contravention to the provisions of Schedule J of Drugs and Cosmetics Act 1940 and Drugs and Magic Remedies Act. Many times drugs are positioned as fairness creams through companies’ advertisements to mislead the public with false claims on enhancing skin complexion and treatment, whereas ideally they are supposed to be advertised or positioned as a drug which requires a prescription for its use as indicated clinically and not to be sold to be used as a cosmetic under the provisions of the law of the land.

     

  7. 7.


    Availability of inappropriate TC combinations: The Kligman formula using TC along with tretinoin and hydroquinone was helpful for the dermatologist in treating melasma aggressively who at the appropriate time switched over to a non-TC maintenance regime. Very soon triple combination including modified Kligman formula containing mid-potency steroids started being misused by physicians and patients alike for various types of hyperpigmentation and as anti-blemish and fairness creams and that too for prolonged period resulting in adverse effects [1, 33].

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Mar 5, 2018 | Posted by in Dermatology | Comments Off on Abuse of Topical Corticosteroid as Cosmetic Cream: A Social Background of Steroid Dermatitis

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